Metal Ions in Biological Systems: Volume 14: Inorganic Drugs in Deficiency and Disease

by Sigel; Helmut

• ISBN13: 9780824715694
• ISBN10: 0824715691
• Format: Hardcover
• Copyright: 1982-02-26
• Publisher: CRC Press

Table of Contents

PREFACE TO THE SERIES	iii
PREFACE TO VOLUME 14	v
CONTRIBUTORS	xi
CONTENTS OF OTHER VOLUMES	xiii
Chapter 1 DRUG-METAL ION INTERACTION IN THE GUT	1	(36)
P.F. D'Arcy and J.C. McElnay
1. Introduction	2	(1)
2. In Vitro Models of Drug Absorption Interactions	3	(6)
3. Interactions with Metal-Containing Antacids or Metal Salts	9	(15)
4. Implications of Absorption Interactions on Drug Pharmacokinetic Profiles	24	(6)
5. Clinical Significance of Drug Absorption Interactions with Metal Ions and Metal-Containing Antacids	30	(1)
References	31	(6)
Chapter 2 ZINC DEFICIENCY AND ITS THERAPY	37	(20)
Ananda S. Prasad
1. History	38	(2)
2. Causes of Human Zinc Deficiency	40	(8)
3. Clinical Manifestations of Zinc Deficiency	48	(2)
4. Laboratory Diagnosis of Zinc Deficiency	50	(2)
5. Treatment of Human Zinc Deficiency	52	(1)
Acknowledgments	53	(1)
References	53	(4)
Chapter 3 THE PHARMACOLOGICAL USE OF ZINC	57	(20)
George J. Brewer
1. History	57	(3)
2. Zinc Absorption	60	(2)
3. Oral Regimens	62	(1)
4. Diseases Which May Respond to Zinc Therapy	63	(4)
5. Mechanism of Action	67	(4)
6. Toxicity	71	(1)
7. The Future	72	(1)
Acknowledgments	72	(1)
References	73	(4)
Chanter 4 THE ANTI-INFLABOTORY ACTIVITIES OF COPPER COMPLEXES	77	(48)
John R.J. Sorenson
1. Introduction	78	(2)
2. Normal Physiology of Copper Complexes	80	(4)
3. Altered Physiology of Copper Complexes in Diseases with Inflammatory Components	84	(6)
4. Pharmacologic Activities of Copper Complexes	90	(12)
5. Clinical Effectiveness of Copper Complexes in the Treatment of Rheumatoid and Other Degenerative Diseases	102	(3)
6. Biochemistry of the Anti-Inflammatory Copper Complexes: Possible Mechanisms of Action	105	(5)
7. Chemistry of Copper Complexes	110	(3)
Acknowledgments	113	(1)
References	113	(12)
Chapter 5 IRON-CONTAINING DRUGS	125	(54)
David A. Brown and M.V. Chidambaram
1. Introduction to the Chemistry of Iron	126	(3)
2. Biochemistry of Iron	129	(17)
3. Diseases Based on Iron	146	(8)
4. Iron Therapy	154	(15)
Glossary of Medical Terms	169	(2)
References	171	(8)
Chapter 6 GOLD COMPLEXES AS METALLO-DRUGS	179	(28)
Kailash C. Dash and Hubert Schmidbaur
1. Introduction	180	(3)
2. Gold Drugs Against Arthritis	183	(11)
3. Gold Poisoning, Contraindications, and Treatment	194	(3)
4. Gold Metabolism (Absorption, Distribution, and Excretion)	197	(1)
5. Physical Methods for Determining Interaction of Gold Drugs In Biological Systems	198	(1)
6. Detection and Estimation of Gold in Biological Systems	199	(1)
References	200	(7)
Chapter 7 METAL IONS AND CHELATING AGENTS IN ANTIVIRAL CHEMOTHERAPY	207	(36)
D.D. Perrin and Hans Stunzi
1. Introduction	207	(3)
2. The Viral Cycle and Its Impact on Host Organisms	210	(3)
3. Interfering with the Viral Cycle	213	(2)
4. Chelation and Biological Activity	215	(3)
5. Chelating Agents with Antiviral Activity	218	(14)
6. Delivery of Drugs to Targets	232	(1)
7. Metal Ions in Antiviral Chemotherapy	233	(1)
Abbreviations	234	(1)
References	235	(8)
Chapter 8 COMPLEXES OF HALLUCINOGENIC DRUGS	243	(14)
Wolfram Hansel
1. Introduction	243	(1)
2. The Chemistry of Hallucinogenic Drugs	244	(3)
3. The Role of Metal Ions In the Actions of Drugs	247	(1)
4. Complexes of Hallucinogenic and Related Drugs	248	(4)
5. Conclusions	252	(1)
Abbreviations	253	(1)
References	253	(4)
Chapter 9 LITHIUM IN PSYCHIATRY	257	(58)
Nicholas J. Birch
1. Introduction	257	(4)
2. Lithium in Psychiatry	261	(11)
3. Chemical Aspects of Lithium	272	(4)
4. Pharmacological and Biochemical Aspects of Lithium	276	(27)
5. Conclusions	303	(1)
References	303	(12)
AUTHOR INDEX	315	(26)
SUBJECT INDEX	341