Metal Ions in Gene Regulation

by Silver, Simon; Walden, William

• ISBN13: 9780412053313
• ISBN10: 0412053314
• Format: Hardcover
• Copyright: 1997-12-01
• Publisher: Kluwer Academic Pub

Summary

This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.

Table of Contents

Contributors	vii
1. Overview of Cellular Inorganic Metabolism and the Need for Gene Regulation	1	(10)
Simon Silver
William Walden
PART I: BACTERIAL METAL METABOLISM	11	(120)
2. Control of Bacterial Iron Transport by Regulatory Proteins	11	(34)
Klaus Hantke
Volkmar Braun
3. Metal Cation Regulation in Gram-Positive Bacteria	45	(32)
John D. Helmann
4. Two-Component Systems in the Regulation of Heavy Metal Resistance	77	(27)
Dietrich H. Nies
Nigel L. Brown
5. Phosphate Signaling and the Control of Gene Expression in Escherichia coli	104	(27)
Barry L. Wanner
PART II: ANIMAL METAL METABOLISM	131	(148)
6. Translational Regulation of Bioiron	131	(26)
Elizabeth C. Theil
7. The Iron Responsive Element (IRE), the Iron Regulatory Protein (IRP), and Cytosolic Aconitase: Posttranscriptional Regulation of Mammalian Iron Metabolism	157	(60)
Richard S. Eisenstein
M. Claire Kennedy
Helmut Beinert
8. Mechanisms for Induction and Rerepression of Ferritin Synthesis	217	(14)
David P. Mascotti
Lisa S. Goessling
Diane Rup
Robert E. Thach
9. Metallothionein Gene Regulation in Mouse Cells	231	(19)
Simon Labbe
Carl Simard
Carl Seguin
10. Menkes' and Wilson's Diseases: Genetic Disorders of Copper Transport	250	(29)
Julian F. B. Mercer
James Camakaris
PART III: LOWER EUKARYOTES AND PLANTS	279	(190)
11. Metal Ion Stress in Yeast	279	(37)
Dennis R. Winge
Andrew K. Sewell
Wei Yu
Joanne L. Thorvaldsen
Rohan Farrell
12. Yeast Metallothionein Gene Regulation	316	(26)
Simon A. B. Knight
Keith A. Koch
Dennis J. Thiele
13. The Molecular Biology of Iron and Zinc Uptake in Saccharomyces cerevisiae	342	(30)
David Eide
14. Metallothionein Gene Regulation in Cyanobacteria	372	(26)
Nigel J. Robinson
Amanda J. Bird
Jennifer S. Turner
15. Metallothionein-like Genes and Phytochelatins in Higher Plants	398	(33)
Anthony P. Fordham-Skelton
Nigel J. Robinson
Peter B. Goldsbrough
16. Regulation of Ferritin Synthesis and Degradation in Plants	431	(19)
Jean-Francois Briat
Stephane Lobreaux
17. Reciprocal, Copper-Responsive Accumulation of Plastocyanin and Cytochrome c(6) in Algae and Cyanobacteria: A Model for Metalloregulation of Metalloprotein Synthesis	450	(19)
Sabeeha Merchant
Index	469