Metathesis in Natural Product Synthesis Strategies, Substrates and Catalysts

by Cossy, Janine; Arseniyadis, Stellios; Meyer, Christophe; Grubbs, Robert H.

• ISBN13: 9783527324408
• ISBN10: 3527324402
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-06-28
• Publisher: Wiley-VCH

Summary

Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this is a comprehensive view of a hot topic. Written by top international authors, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. A real must-have for anyone working in natural product synthesis.

Author Biography

Janine Cossy graduated from the University of Reims. After a postdoctoral stay with Barry Trost (1980-1982) at the University of Wisconsin, she returned to Reims where she became Director of Research of the CNRS in 1990. In the same year she moved to Paris to become Professor of Organic Chemistry at the ESPCI (Ecole Sup?rieure de Physique et de Chimie Industrielles de la Ville de Paris). She has published more than 330 articles and 12 patents in the field of synthetic organic chemistry and natural product synthesis. She is Associate Editor at Organic Letters since 2005.

Stellios Arseniyadis completed his PhD in 2002 under the guidance of Dr. C. Mioskowski at the Universit? Louis Pasteur (Strasbourg, France). He then joined the Research & Innovation team at Rhodia Chirex (Boston, USA) to work on the development of palladium-catalyzed coupling reactions. In 2003, he began a postdoc with Professor A.C. Spivey at Imperial College (London, UK) and, in 2004, joined Professor K.C. Nicolaou?s group at The Scripps Research Institute (La Jolla, USA).
In 2005, he was appointed a permanent CNRS researcher position in the group of Professor Cossy. His research interests include the development of new methods in the field of asymmetric catalysis and their application to the total synthesis of natural products.


Christophe Meyer graduated from the Ecole Nationale Sup?rieure de Chimie de Paris in 1991 and received his PhD from University Pierre et Marie Curie (Paris) in 1994 under the supervision of Professor J.-F. Normant and Doctor I. Marek. After a postdoctoral stay at the University of Toronto (Canada) in the laboratory of Professor M. Lautens, he was appointed a CNRS researcher position in 1996 in the group of Professor J. Cossy (ESPCI) and became Director of Research in 2008. His research focuses on the development of synthetic methodologies and total synthesis of natural products.

Table of Contents

Synthesis of Natural Products Containing Medium-Size Carbocycles by Ring-Closing Alkene Metathesis

Natural Products Containing Medium-Sized Nitrogen Heterocycles Synthesized by Ring-Closing Alkene Metathesis

Synthesis of Natural Products Containing Medium-Size Oxygen Heterocycles by Ring-Closing Alkene Metathesis

Phosphorus and Sulfur Heterocycles via Ring-Closing Metathesis: Application in Natural Product Synthesis

Synthesis of Natural Products Containing Macrocycles by Alkene Ring-Closing Metathesis

Synthesis of Natural Products and Related Compounds Using Ene-Yne Metathesis

Ring-Closing Alkyne Metathesis in Natural Product Synthesis

Temporary Silicon-Tethered Ring-Closing Metathesis Reactions in Natural Product Synthesis

Metathesis Involving a Relay and Applications in Natural Product Synthesis

Cross-Metathesis in Natural Products Synthesis

Cascade Metathesis in Natural Product Synthesis

Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis

Metathesis Reactions in Solid-Phase Organic Synthesis

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