Preface | |
Editors | |
History and Heritage | |
Introduction | |
Galegine and antidiabetic plants | |
Discovery of metformin | |
Introduction of metformin into clinical practice: the French innovation | |
Metformin: a chemical perspective | |
Pharmaceutical development of metformin | |
Efficacy | |
Introduction | |
Defining the clinical utility of metformin: reflections from Scotland | |
Metformin in combination | |
Metformin in children and adolescents with type 2 diabetes | |
Dose-related antihyperglycaemic efficacy of metformin | |
Understanding the glucose-lowering actions of metformin | |
Focus on metformin and body weight | |
Insights into the effects of metformin on the lipid profile | |
Cardiovascular Benefits | |
Introduction | |
Metformin and cardiovascular protection: lessons from the UK Prospective Diabetes Study | |
Survival benefits of metformin in high-risk populations | |
Mechanisms of vascular protection with metformin | |
Health Outcomes | |
Introduction | |
Defining the health economic benefits of metformin | |
Impact of metformin on quality of life | |
Safety | |
Introduction | |
Tolerability of metformin | |
Measures to improve the gastrointestinal tolerability of metformin | |
Defining the risk of lactic acidosis | |
Defining patient populations not indicated for metformin | |
Guidelines | |
Introduction | |
The role of metformin in setting treatment standards within management guidelines | |
Future Indications | |
Introduction | |
The potential of metformin for diabetes prevention | |
The role of metformin in polycystic ovary syndrome and infertility | |
Potential of metformin in the management of insulin-resistant states | |
The potential of metformin for the treatment of neoplastic disease | |
Future role of metformin in healthcare therapy | |
The metformin 50-year roll of honour | |
Index | |
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