Methods of Cancer Diagnosis, Therapy, and Prognosis

by Hayat, M. A.

• ISBN13: 9781402088995
• ISBN10: 140208899X
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-12-30
• Publisher: Springer Verlag

Summary

This third volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis discusses diagnosis, therapy, and prognosis of Gastrointestinal Cancers. Both standard and emerging therapies for these cancers, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume * Includes various aspects of esophageal cancer, gastric cancer, and pancreatic cancer* Highlights the methodologies used for diagnosis, therapy, and prognosis of these different cancers* Explains the molecular mechanisms underlying these cancers* Discusses the evaluation of FDG-PET/CT fusion imaging, endoscopic ultrasound and imaging, and the role of microRNA in prognosis* Details the classification of colon and gastric histological samples* Highlights treatments, including radiofrequency ablation and surgical debulking, endoscopic submucosal dissection, laparoscopic gastrectomy of gastric cancer and pancreaticoduodenectomy* Reviews use of radiotherapy and chemotherapy for pancreatic cancer patients * Discusses a large number of imaging modalities for diagnosing these cancers and assessing the different treatmentsProfessor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

Table of Contents

Gastrointestinal Cancers

Introduction: Gastrointestinal Cancersm

Gastrointestinal Stromal Tumors (GISTs) Gastric Canceresophageal Cancer Treatments

References

Metastatic Gastrointestinal Cancer: Safety of Cisplatin Combined with Continuous 5

Fluorouracil Versus Bolus 5

Fluorouracil and Leucovorin (Methodology)

Introduction

Patients and Methods

Results

Discussion

References

Gastrointestinal Cancer: Endoscopic Submucosal Dissection (Methodology) Atsushi Imagawa

Introduction

Indications

Method and Discussion

Setting of a High-Frequency Generator

Complications

Esophageal and Colorectal Lesions

References

Gastrointestinal Epithelial Neoplasms: Endoscopic Submucosal Dissection (Methodology)Mitsuhiro Fujishiro

Introduction

Application

Endoscopic Systems and Equipment

Procedure

Marking Around the Lesion

Submucosal Injection

Bleeding

Perforation

Management After Endoscopic Submucosal Dissection

Further Considerations

References

Inoperable Abdomino-Pelvic Tumors: Treatment with Radiofrequency Ablation and Surgical Debulking Nathan W. Pearlman

Introduction

Technique

Patient Population and Results

References

Gastrointestinal Neuroendocrine Tumors: Diagnosis Using Gastrin Receptor Scintigraphymartin Gotthardt

Neuroendocrine TUMORS

Symptoms, Clinical Appearance, Therapy, and Prognosis

Diagnostic Imaging Procedures

Potential Improvement of Scintigraphic Imaging of NET by Using Alternative Radiopeptides

Radiopeptide Scanning Versus Anatomical Imaging Modalitiesradiolabeled Peptides: Development, Advantages and Short

Comingsminigastrin for Detecting Metastasized Neuroendocrine TUMORS

Cholecystokinine 2 (CCK2) Receptor Expression

Labeling

Scanning Protocol

Biodistribution of MG

Clinical Imaging in Neuroendocrine Tumors

Future Perspectives of DGlu1-MInigastrin

References

Esophageal Cancer

Distal Esophagus: Evaluation of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Fusion Imaging Domenico Rubello and Cristina Nanni

Introduction

18F-FDG-PET and PET/CT in Esophageal CANCER

Positivity Criteria

Staging Disease Relapse

Neoadjuvant Therapy Response18F-FDG-PET/CT Versus Other Techniquespet/CT and Other Radiotracers

References

Endoscopic Ultrasound and Staging of Esophageal CANCERKanwar R.S. Gill and Timothy Woodward

Objectives

Basic Principles

Equipment

Procedure and TNM Classificationrole of Endoscopic Ultrasound-Fine Needle Aspiration in Esophageal Cancerendoscopic Ultrasound in Assessing Primary Tumor (T Staging)

Endoscopic Ultrasound in Assessing Nodal Metastasisendoscopic Ultrasound in Assessing Distance Metastasisrestaging of Esophageal Cancer

After Chemoradiation

Endoscopic Ultrasound-Fine-Needle Aspiration Molecular Diagnosis of Esophageal Cancercomplications and Safety

References

Esophageal Cancer: Role of Rnasen Protein and Micro-RNA in Prognosis Hideyuki Ishiguro, Yoshiyuki Kuwabara, Nobuyoshi Sugito, and Yoshitaka Fujii

Introduction

Real-Time Reverse Transcription Analysis Using TaqMan PROBES

Isolation of RNA from Tumor Samples and Reverse Transcription Reaction

Real-Time Polymerase Chain Reaction Using TaqMan Probes

Immunohistochemistry of Rnasen

References

Esophageal Cancer: Initial StaginGLana Y. Schumacher

Introduction

Preoperative Staging Modalitiesprimary Tumor (T Stage)

Regional Lymph Node (N Stage)

Metastatic Disease (M Stage)

Thoracoscopic and Laparoscopic Stagingrestaging After Neoadjuvant Therapytreatment Overview

References

Gastric Cancer

Automated Disease Classification of Colon and Gastric Histological Samples Based on Digital Microscopy and Advanced Image Analysis Levente Ficsor and Bela Molnar

Introduction

Materials and Methods

Samples Digitizing of Glass Slides

Developer Tools

Detection of Cells, Tissue Components, and Struc

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