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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2008-12-26
  • Publisher: Springer Verlag

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Combinatorial chemistry is used to find materials that form sensor micoarrays. This book discusses the fundamentals, and then proceeds to the many applications of microarrays, from measuring gene expression (DNA microarrays) to protein-protein interactions, peptide chemistry, carbodhydrate chemistry, electrochemical detection, and microfluidics.

Table of Contents

Types of arrays currently available.- Optical methods of detection of events on the chip surface.- Electrochemical Detection.- Integrated Microfluidic Devices for Automating DNA Microarray Process.- Self-contained, Fully Integrated Biochip for Sample Preparation, PCR Amplification, and DNA Microarray Detection.- Spot identification and data evaluation.- Statistical data analysis.- Electrochemical output and data analysis.- Uses of DNA Microarrays.- Peptide Arrays: towards Routine Implementation.- Antibody Microarrays for the Detection of Toxins.- Autoantibody Profiling Using Synovial Proteome Microarrays.- Carbohydrate microarrays for the Recognition of Microbes and Host Cells.- Development of the Living Cell Array.- Assembly of Multicellular Cell Microarrays Using Magnetic Nanowires.- Combinatorial Organic Chemistry for Future Drug Development and Screening.- Cystic Fibrosis Carrier Screening Test Performed Using a Microarray Platform Based on Electrochemical Detection of DNA Hybridization.- Frequency Dependent and Surface Characterization of DNA Imoobilization and Hybridization (IMEs).- Integrated Potentiostat Circuit for CMOS Sensor Chips.- Use of other redox enzyme systems.- Detection of single micron-sized magnetic bead and magnetic nanoparticles using spin valve sensors for biological applications.- Magnetic Labeling and Detection of Biomolecules using the Bead ARray Counter (BARC) Biosensors.- High Performance Optical Biodetection Using Encapsulated SERS-Active Nanoparticles.- Multiplex sensors using carbon nanotubes and nanowires.- Bar-coding using platforms for nucleic acid and protein recognition.- Electrochemical nanoparticle based sensors.

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