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9780824740412

Microbial Genomics and Drug Discovery

by ;
  • ISBN13:

    9780824740412

  • ISBN10:

    0824740416

  • Format: Hardcover
  • Copyright: 2003-05-14
  • Publisher: CRC Press

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Summary

Pfizer, Inc., Groton, CT. Examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. Describes procedures to recognize common targets in bacterial species for the design of broad-spectrum antibiotics. For researchers.

Table of Contents

Preface iii
Contributors ix
Global Aspects of Antibiotic Resistance
1(8)
Julian Davies
Genomics of Bacterial Pathogens
9(18)
Steven R. Gill
Karen E. Nelson
Claire M. Fraser
Bioinformatics, Genomics, and Antimicrobial Drug Discovery
27(16)
Brian A. Dougherty
Daniel B. Davison
The Pathway Tools Software and Its Role in Antimicrobial Drug Discovery
43(12)
Peter D. Karp
Genomic Strategies in Antibacterial Drug Discovery
55(16)
Christopher P. Gray
Wolfgang Keck
Genomics-Based Approaches to Novel Antimicrobial Target Discovery
71(26)
Thomas J. Dougherty
John F. Barrett
Michael J. Pucci
Pathogenesis Genes as Novel Targets
97(14)
Andrea Marra
Application of Genomics to the Discovery of New Drugs Against Tuberculosis
111(24)
Richard A. Slayden
Dean C. Crick
Michael R. McNeil
Patrick J. Brennan
Phenotype MicroArrays: Their Use in Antibiotic Discovery
135(12)
Barry R. Bochner
Microbial Proteomics: New Approaches for Therapeutic Vaccines and Drug Discovery
147(26)
C. Patrick McAtee
Surrogate Ligand-Based Assay Systems for Discovery of Antibacterial Agents for Genomic Targets
173(14)
Dale J. Christensen
Paul T. Hamilton
Expression Profiling Uses in Antibacterial Chemotherapy Development
187(14)
Paul M. Dunman
Steven J. Projan
Using Fungal Genomes for the Discovery, Development, and Clinical Application of Novel and Current Antifungal Therapeutics
201(20)
Todd A. Black
Joan K. Brieland
Jonathan Greene
Catherine Hardalo
Scott S. Walker
Guillaume Cottarel
Genomics in Novel Natural Products Generation
221(18)
Zhiqiang An
William R. Strohl
Index 239

Supplemental Materials

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