The Microbial Models of Molecular Biology From Genes to Genomes

by Davis, Rowland H.

• ISBN13: 9780195154368
• ISBN10: 0195154363
• Format: Hardcover
• Copyright: 2003-09-11
• Publisher: Oxford University Press

Summary

This book explains the role of simple biological model systems in the growth of molecular biology. Essentially the whole history of molecular biology is presented here, tracing the work in bacteriophages in E. coli, the role of other prokaryotic systems, and also the protozoan and algal models - Paramecium and Chlamydomonas, primarily - and the move into eukaryotes with the fungal systems - Neurospora, Aspergillus and yeast. Each model was selected for its appropriateness for asking a given class of questions, and each spawned its own community of investigators. Some individuals made the transition to a new model over time, and remnant communities of investigators continue to pursue questions in all these models, as the cutting edge of molecular biological research flowed onward from model to model, and onward into higher organisms and, ultimately, mouse and man.

Author Biography

Rowland H. Davis received his A.B. and Ph.D. degrees from Harvard University. He did postdoctoral work at the California Institute of Technology and held academic appointments at the University of Michigan and, currently, at the University of California, Irvine

Table of Contents

1. Model Systems, Model Organisms,	3	(12)
2. Morgan's Progeny,	15	(12)
3. Neurospora,	27	(20)
4. Aspergillus,	47	(14)
5. Yeast,	61	(12)
6. Leaving the Fungi,	73	(7)
7. Escherichia coli,	80	(19)
8. The T Bacteriophages,	99	(13)
9. Temperate Phages and Transduction,	112	(11)
10. DNA,	123	(7)
11. Prokaryotes Take Center Stage,	130	(24)
12. Prokaryotes: Later Contributions,	154	(10)
13. Cytoplasmic Inheritance: The Ciliates,	164	(19)
14. Organelle Genetics: Yeast and Chlamydomonas,	183	(16)
15. Yeast Becomes a Supermodel,	199	(17)
16. The Filamentous Fungi: Eclipse and Renewal,	216	(13)
17. The Role of Biochemistry,	229	(9)
18. Genomics,	238	(12)
19. The Age of Model Organisms,	250	(11)
Appendix 1. Life Cycles and Genetic Principles,	261	(10)
Appendix 2. Macromolecules and the Central Dogma,	271	(10)
Appendix 3. Genetic Engineering,	281	(4)
Notes,	285	(18)
References,	303	(20)
Name Index,	323	(6)
Subject Index,	329