The Microbial Cell | |
Microbial Life | |
Origin and Discovery | |
Presents the history of microbial discovery from ancient times up to the present day | |
Including twentieth-century discoverers of gene cloning | |
The archaeal domain, and the ubiquity of horizontal gene transfer | |
Observing the Microbial Cell | |
Presents microscopy as the key tool of microbial discovery | |
From an in-depth treatment of light microscopy and electron microscopy to examples of confocal fluorescence and scanning probe microscopy | |
In-depth coverage of microscopy helps the student evaluate models of the cell presented in Part II | |
Genes and Genomes, and Part III, Metabolism and Biochemistry | |
Cell Structure and Function | |
Emphasizes the functional unity of the cell, from envelope to nucleoid | |
Coverage includes envelope diversity (Gram positive, Gram negative, mycobacteria, and archaea) | |
Up-to-date models of the prokaryotic cytoskeleton, and nucleoid organization | |
The organization of DNA and RNA synthesis points to detailed exploration in Part II | |
Bacterial culture, Growth, and Development | |
Introduces the fundamental classes of metabolism, to be developed further in Part III | |
Developmental diversity includes biofilm formation, sporulation, and multicellular fruiting body cycles | |
Environmental Influence and Control of Microbial Growth | |
Presents extreme environments and microbial adaptations, as well as practical applications for control | |
Environmental topics are further explored in Part IV | |
Microbial Diversity and Ecology, while pathogens and their control are pursued in Part V | |
Medicine and Immunology | |
Virus Structure and Function | |
Includes up-to-date visualization methods such as cryo-EM as well as fluorescent-focus assays | |
Viral genetics is introduced in preparation for the key roles viruses play in microbial genetics, which is covered in Part II | |
Genes and Genomes | |
Genomes and Chromosomes | |
Presents the structure and function of microbial DNA | |
Emphasizing unity of mechanism as well as diversity of genome structure | |
Such as the existence of multiple linear and circular | |
Chromosomes within some bacteria | |
Transcription, Translation, and Bioinformatics | |
Presents gene expression, from transcription and translation through chaperone-assisted folding and transmembrane secretion | |
It also describes how knowledge of genes and proteins led to the science of bioinformatics | |
Gene Transfer, Mutations, and Genome Evolution | |
Emphasizes the multiple means of prokaryotic gene transfer, including its relevance to the evolution of pathogens and hosts | |
Intriguing variations include the role of the transformation apparatus in enabling bacteria to consume DNA for energy | |
Molecular Regulation | |
Presents current models of molecular regulation | |
With relevance to survival in natural ecosystems and in host organisms | |
Viral Molecular Biology | |
Treats examples of viruses in depth | |
Emphasizing diversity of molecular mechanisms | |
Such as primers consisting of host-derived proteins or transfer RNA | |
Molecular Techniques and Biotechnology | |
Presents research approaches and practical examples of applying molecular genetics to microbial discovery | |
Metabolism and Biochemistry | |
Energetics and Catabolism | |
Presents the thermodynamic basis of microbial energetics, including emerging catabo | |
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