The Migraine Brain Imaging Structure and Function

by Borsook, David; May, Arne; Goadsby, Peter J.; Hargreaves, Richard

• ISBN13: 9780199754564
• ISBN10: 019975456X
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-07-05
• Publisher: Oxford University Press

Summary

The Migraine Brain, edited by David Borsook, Arne May, Peter J. Goadsby, and Richard Hargreaves, makes a major contribution to the field, addressing the increasingly sophisticated neuroimaging techniques that have allowed researchers to begin to define functional and anatomical characteristics of migraine and other less-common types of headache. Of particular focus is how imaging is changing the way we understand migraine. This includes changes in function, structure and chemistry of the migraine brain. Include are section that focus on particular aspects of migraine, for example the migraine aura: those symptoms that cause visual sensitivity (blinding white light), sensory difficulty (loud noises, painful touch, and hot/cold spells), slurred language, and motor dysfunction. Extensively illustrated throughout,The Migraine Brainprovides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches. A collation of the top thinkers in the field and the only book of its kind,The Migraine Brainis necessary reading for neurologists and neuroscientists.

Table of Contents

Migraine: History

A History of Migraine

Neurobiology of the Migraine Brain

Migraine - Some Theories and Controversies

Neural System Changes in Migraine

Sensitization of Trigeminovascular Pathway: Implications to Migraine Pathophysiology

Brain Measures of the Interictal Migraine Brain State (IMBS)

From Episodic to Chronic Migraine

Concomitant Symptoms in Migraine

Clinical Perspective

Clinical Neuroimaging of Migraine

Prophylaxis: What Measures?

Iron Accumulation in Migraine

Migraine and Brain Lesions

Clinical Utility of Objective Measures

Migraine Genes - Clinical and Preclinical Perspectives

Imaging Migraine

In Search of Future Treatments

Imaging migraine: A history

Focus on the Midbrain

Diffusion Weighted Imaging in Migraine

Diffusion Tensor Imaging Abnormalities in Migraine

Morphometric changes and VBM

Surface-Based Structural Changes in Migraine

Changing receptors in Migraine state

15O PET studies in migraine

Imaging activation in the migraine state

Metabolites and migraine

Visual aura

Functional Imaging of the Migraine Brain: New Insights into Brain Dysfunction

TMS and MEG studies in migraine

Magnetic Resonance Angiography and Migraine

Transcranial Magnetic Stimulation (TMS) / Repetitive Transcranial Magnetic Stimulation (rTMS)

Measures of cortical excitability

Drug Effects on Cortical Excitability

Conclusions

Defining the Migraine Phenotype

The Future of Imaging in Migraine Diagnosis and Treatment

Can Imaging Effectively Transform Migraine Treatment?

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