Mild Cognitive Impairment Aging to Alzheimer's Disease

by Petersen, Ronald C.

• ISBN13: 9780195123425
• ISBN10: 0195123425
• Format: Hardcover
• Copyright: 2003-01-09
• Publisher: Oxford University Press

Summary

What are the boundary zones between normal aging and Alzheimer's disease (AD)? Are many elderly people whom we regard as normal actually in the early stages of AD? Alzheimer's disease does not develop overnight; the early phases may last for years or even decades. Recently, clinicalinvestigators have identified a transitional condition between normal aging and and very early Alzheimer's disease that they have called mild cognitive impairment, or MCI. This term typically refers to memory impairment beyond what one would expect in individuals of a given age whose otherabilities to function in daily life are well preserved. Persons who meet the criteria for mild cognitive impairment have an increased risk of progressing to Alzheimer's disease in the near future. Though many questions about this condition and its underlying neuropathology remain open, fullclinical trials are currently underway worldwide aimed at preventing the progression from MCI to Alzheimer's disease. This book addresses the spectrum of issues involved in mild cognitive impairment, and includes chapters on clinical studies, neuropsychology, neuroimaging, neuropathology,biological markers, diagnostic approaches, and treatment. It is intended for clinicians, researchers, and students interested in aging and cognition, among them neurologists, psychiatrists, geriatricians, clinical psychologists, and neuropsychologists.

Table of Contents

Contributors	xiii
Conceptual Overview	1	(14)
Ronald C. Petersen
Clinical Features	15	(26)
Ronald C. Petersen
John C. Morris
Neuropsychiatric Symptoms	41	(22)
Jeffrey L. Cummings
Normative Neuropsychology	63	(26)
Glenn E. Smith
Robert J. Ivnik
Optimizing Cognitive Test Norms for Detection	89	(16)
Martin Sliwinski
Richard Lipton
Herman Buschke
Christina Wasylyshyn
Magnetic Resonance Imaging	105	(28)
Clifford R. Jack Jr.
Functional Imaging	133	(16)
Keith A. Johnson
Marilyn S. Albert
Spectrum of Pathology	149	(42)
Heiko Braak
Kelly Del Tredici
Eva Braak
Neuropathological Changes in Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease	191	(14)
Teresa Gomez-Isla
Bradley T. Hyman
Biological Markers	205	(24)
Neill R. Graff-Radford
Clinical Evaluation	229	(14)
Ronald C. Petersen
Treatment of Mild Cognitive Impairment and Prospects for Prevention of Alzheimer's Disease	243	(16)
David S. Knopman
Index	259