What is included with this book?
Introduction | p. 1 |
What is mild cognitive impairment? | p. 3 |
Epidemiological studies of MCI | p. 5 |
The border zone between aging and dementia: cognitive and neuropathological changes | p. 10 |
Aging and cognitive performance | p. 11 |
Neuropathology of Alzheimer's disease, non-demented aging and MCI | p. 17 |
Histopathological features | p. 17 |
Plaques | p. 18 |
Neurofibrillary pathology | p. 18 |
Neuronal loss | p. 19 |
Topography of neuropathological changes | p. 22 |
Neuropathological AD diagnosis | p. 24 |
Neuropathology of aging | p. 27 |
Neuropathology of MCI | p. 31 |
Does a subset of MCI patients actually have early Alzheimer's disease? | p. 32 |
Clinical studies | p. 32 |
Neuroimaging | p. 32 |
Detecting and diagnosing MCI and early AD | p. 35 |
Early detection | p. 35 |
Recognition of MCI and early AD | p. 36 |
Informant-based history | p. 39 |
Neurological examination | p. 41 |
Laboratory and radiological evaluation | p. 42 |
Psychometric/mental status testing | p. 44 |
Dementia-screening instruments | p. 45 |
Mini-mental state examination | p. 45 |
Clock-drawing test | p. 46 |
Seven-minute screen | p. 48 |
Dementia staging instruments | p. 49 |
CDR | p. 49 |
Global deterioration scale | p. 50 |
Etiology of MCI: differential diagnosis | p. 53 |
"Worried-well" | p. 53 |
Depression | p. 54 |
Other etiologies | p. 55 |
Neurodegenerative dementias | p. 55 |
Overlap disorders | p. 58 |
Dementia with Lewy bodies | p. 58 |
Vascular dementia | p. 59 |
Frontotemporal lobar dementias | p. 60 |
Identifying the subset of MCI that is AD | p. 65 |
Treatment of MCI and dementia | p. 69 |
MCI | p. 69 |
The case for early treatment | p. 69 |
Non-pharmacological treatment | p. 71 |
Dementia therapy | p. 73 |
Approved therapies | p. 73 |
Cholinergic hypothesis | p. 73 |
Cholinesterase inhibitors | p. 75 |
Donepezil | p. 77 |
Rivastigmine | p. 78 |
Galantamine | p. 79 |
Memantine | p. 79 |
Agents under investigation for AD treatment and prevention | p. 81 |
Vitamin E and selegiline | p. 81 |
Estrogen | p. 82 |
Anti-inflammatory agents | p. 83 |
Cholesterol-reducing agents | p. 84 |
Chelation therapy | p. 84 |
Future therapeutic and diagnostic strategies | p. 85 |
Amyloid hypothesis | p. 85 |
Secretase inhibitors | p. 87 |
Amyloid vaccine | p. 88 |
Potential biomarkers | p. 89 |
CSF biomarkers | p. 90 |
CSF amyloid beta (A[beta]) | p. 91 |
CSF tau | p. 91 |
CSF sulfatide | p. 92 |
CSF markers of inflammation | p. 93 |
CSF markers of oxidative stress | p. 93 |
Serum biomarkers | p. 94 |
Structural imaging | p. 95 |
Functional neuroimaging | p. 96 |
PET and SPECT | p. 97 |
Functional MRI (fMRI) | p. 98 |
Imaging amyloid | p. 100 |
Genetic testing | p. 101 |
Early-onset familial AD | p. 102 |
Amyloid precursor protein | p. 102 |
Presenilin genes | p. 103 |
Late-onset AD | p. 103 |
Apolipoprotein E | p. 104 |
Case studies | p. 105 |
MCI as early-stage Alzheimer's disease | p. 105 |
Comment | p. 108 |
Diagnosis of dementia prior to impairment sufficient for MCI | p. 110 |
Comment | p. 113 |
Memory complaints associated with non-demented aging | p. 118 |
Comment | p. 121 |
References | p. 123 |
Index | p. 143 |
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