Mitochondria

by Schaffer, Stephen W.; Suleliman, M. Saadah

• ISBN13: 9780387699448
• ISBN10: 0387699449
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-09-20
• Publisher: Springer Verlag

Summary

This book covers the important role that Mitochondria play in metabolic pathways, regulation of cytosolic constituents, initiating signal pathways, regulation of apoptosis, and modulating cellular hypertrophy and proliferation.

Author Biography

Dr. Stephen W. Schaffer is a professor at the University of South Alabama. He is a member of the editorial board of Molecular and Cellular Biochemistry.Dr. M.-Saadeh Suleiman is a professor at the University of Bristol, UK. His research includes investigating the role of metabolites and ionic species in myocardial protection, with special emphasis on amino acids, mitochondria, Ca2+ loading and reactive oxygen species.

Table of Contents

Mitochondrial Metabolism
Regulation of Mitochondrial Respiration in Heart Muscle	p. 3
Regulation of Fatty Acid Oxidation of the Heart	p. 27
Regulation of Mitochondrial Fuel Handling by the Peroxisome Proliferator-Activated Receptors	p. 63
Molecular Structure of the Mitochondrial Citrate Transport Protein	p. 97
Regulation of Pyruvate and Amino Acid Metabolism	p. 117
Amino Acids and the Mitochondria	p. 151
The Dynamic Nature of the Mitochondria
Mechanotransduction of Shear-Stress at the Mitochondria	p. 169
Mitochondria as Initiators of Cell Signaling
Formation of Reactive Oxygen Species in Mitochondria	p. 185
Mitochondrial Calcium: Role in the Normal and Ischaemic/ Reperfused Myocardium	p. 197
Mitochondrial Ion Channels	p. 221
Mitochondria as Initiators of Cell Death
The Mitochondrial Permeability Transition Pore - from Molecular Mechanism to Reperfusion Injury and Cardioprotection	p. 241
The Apoptotic Mitochondrial Pathway - Modulators, Interventions and Clinical Implications	p. 271
The Role of Mitochondria in Necrosis Following Myocardial Ischemia-Reperfusion	p. 291
Mitochondria as Modulators of Cell Death
Mitochondria and Their Role in Ischemia/Reperfusion Injury	p. 305
Mitochondrial DNA Damage and Repair	p. 323
Index	p. 349
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