Modern Hematology

by Munker, Reinhold; Hiller, Erhard; Glass, Jonathan, M.D.; Paquette, Ronald; Koeffler, H. Phillip, M.D.

• ISBN13: 9781588295576
• ISBN10: 1588295575
• Edition: 2nd
• Format: Hardcover
• Copyright: 2007-03-30
• Publisher: Humana Pr Inc

Summary

Reinhold Munker and his distinguished colleagues have updated and expanded Modern Hematology: Biology and Clinical Management, now in its second edition, to reflect the major advances in the understanding, diagnosis, and treatment of blood disorders. Modern Hematology: Biology and Clinical Management, Second Edition describes the latest clinical and scientific developments, including molecular studies used to diagnose a variety of hematological disorders and guide their treatment. Targeted and molecular therapies are discussed in detail, including kinase inhibitors in myeloproliferative disorders and humanized monoclonal antibodies. The use of peripheral blood and umbilical cord blood stem cells for transplantation is described, as well as the rationale and indications for non-myeloablative transplantation, emphasizing the preferability of immunotherapy over cytotoxic chemotherapy. Modern Hematology: Biology and Clinical Management, Second Edition brings together facts, concepts, and protocols important for the practice of hematology. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest. The first two chapters introduce the reader to the scientific basis of blood disorders. As in the previous edition, each chapter is illustrated by tables, figures, and a selection of color plates. Experts in pediatric hematology, myeloma, blood transfusion, hemoglobinopathies, pharmacology, and infectious diseases have expanded the scope of Modern Hematology. Comprehensive and informative, Modern Hematology: Biology and Clinical Management, Second Edition is an invaluable resource for medical students, hematology trainees, residents, nurses, nurse practitioners, and physicians in other specialties treating patients with benign and malignant blood disorders.

Table of Contents

Foreward	p. v
Preface	p. vii
Contributors	p. xi
Color Plates	p. xiii
Basic Biology of Hemopoiesis	p. 1
Molecular Biology and Cytokines	p. 19
Supportive Care in Hematology	p. 41
Transplantation of Stem Cells From Bone Marrow, Peripheral Blood, and the Umbilical Cord	p. 63
Anemias: General Considerations and Microcytic, and Megaloblastic Anemias	p. 83
Hemolytic Anemias	p. 101
Leukocytosis, Leukopenia, and Other Reactive Changes of Myelopoiesis	p. 127
The Myeloproliferative Syndromes	p. 137
Acute Myelogenous Leukemias	p. 155
Acute Lymphoblastic Leukemias	p. 173
Myelodysplastic Syndromes	p. 195
Aplastic Anemias	p. 207
Lymphocytosis, Lymphocytopenia, Lymphadenopathy, and Splenomegaly	p. 217
Hodgkin's Lymphoma	p. 225
The Non-Hodgkin's Lymphomas	p. 237
Multiple Myeloma and Related Paraproteinemias	p. 271
Congenital and Acquired Immunodeficiencies	p. 295
Infections Relevant to Hematology	p. 315
Basic Principles of Hemostasis	p. 327
Bleeding Disorders	p. 347
Thrombophilia, Thromboembolic Disease, and Antithrombotic Therapy	p. 381
Transfusion Medicine and Immunohematology	p. 401
Storage Disorders in Hematology	p. 433
Appendices
Glossary of Cytostatic Drugs and Targeted Therapies	p. 441
CD Nomenclature for Human Leukocyte Antigens	p. 455
Laboratory Values	p. 463
Program Requirements for Residency and Fellowship Education in Hematology	p. 465
Databases in Hematology	p. 467
Index	p. 475
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