Modern Synthetic Methods in Carbohydrate Chemistry From Monosaccharides to Complex Glycoconjugates

by Werz, Daniel B.; Vidal, Sebastien; Crich, David

• ISBN13: 9783527332847
• ISBN10: 3527332847
• Edition: 1st
• Format: Hardcover
• Copyright: 2013-12-23
• Publisher: Wiley-VCH

Summary

The fields of glycochemistry and glycoscience are rich and varied and where much can be learned from Nature. As Nature is not always able to produce carbohydrates in quantities useful for not only in research but also as therapeutic agents, new ways need to be found to optimize the yield. This book presents an overview of the latest developments in the field of carbohydrates, ranging from de-novo approaches via cyclodextrin chemistry to the synthesis of such highly complex glycoconjugates as glycosphingolipids and GPI anchors.

The main emphasis remains on the synthetic aspects making the book an excellent source of information for those already involved in carbohydrate chemistry, as well as for those organic chemists who are beginners in this field. Equally of interest to synthetic chemists, as well as medicinal chemists and biochemists.

Author Biography

Daniel B. Werz is Emmy Noether Assistant Professor at the University of Goettingen, Germany. Having obtained his academic degrees from University of Heidelberg he spent over two years of postdoctoral research with Peter H. Seeberger at ETH Zurich, Switzerland before taking up his present position in Goettingen. Dr. Werz has authored and co-authored over 85 scientific publications and has received several scientific fellowships and awards, including the Ruprecht Karls Award of the University of Heidelberg (2004), a Feodor Lynen Fellowship of the Alexander von Humboldt Foundation (2004), the Klaus Grohe Award of the German Chemical Society (2006), the Glyco Thera Award (2010) and a Dozentenstipendium of the Fonds of the Chemical Industry (2011).

S?bastien Vidal is Charg? de Recherche at Centre National de la Recherche Scientifique (CNRS) and is responsible of a small research team at ICBMS (Universit? Claude Bernard Lyon 1, France). In 2000, he has obtained his PhD in organic chemistry from Universit? Montpellier II (Montpellier, France) working on mannose 6-phosphate analogues. He then continued as a postdoctoral fellow in the group of J. Fraser Stoddart at University of California, Los Angeles (UCLA, USA) for 3 years to design synthetic methodologies for the preparation of glycodendrimers. After another postdoctoral position at the National Renewable Energy Laboratory (NREL, Golden, Colorado, USA) under the guidance of Joseph J. Bozell, he then moved back to France and was appointed as a CNRS fellow in 2004. Dr. Vidal has co-authored over 40 scientific publications all devoted to carbohydrate chemistry.

Table of Contents

Advances in Cyclodextrin Chemistry
Au-Catalyzed Glycosylation
de-novo Approaches to Carbohydrates
Synthesis of Bacterial Carbohydrate Antigens
Novel Approaches to Complex Glycosphingolipids
Chemical Synthesis of GPI Anchors
Fluorous tagged carbohydrates for the synthesis of oligosaccharides
Oligosaccharide Synthesis with Furanoses
Synthesis of Sialidase Inhibitiors
Synthesis of Sulfated Oligosaccharides and Heparan Sulfates
Design and synthesis of GM1 glycomimetics
Organic Synthesis of Iduronic Acids
Synthetic methodologies towards aldoheptoses