Modern Therapeutics in Rheumatic Diseases

by Tsokos, George C.

• ISBN13: 9780896039162
• ISBN10: 0896039161
• Format: Hardcover
• Copyright: 2001-11-01
• Publisher: Humana Pr Inc

Summary

Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.

Table of Contents

Preface	v
List of Contributors	xi
I. Rheumatoid Arthritis
Larry W. Moreland
New Treatment Opportunities for Rheumatoid Arthritis	3	(8)
Larry W. Moreland
Genetic Influences on Treatment Response in Rheumatoid Arthritis	11	(12)
S. Louis Bridges Jr.
Robert P. Kimberly
Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis	23	(24)
John S. Sundy
Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs	47	(18)
M. Elaine Husni
Lee S. Simon
Glucocorticoid Therapy in Rheumatoid Arthritis	65	(24)
Kenneth G. Saag
John R. Kirwan
Anti-Tumor Necrosis Factor Agents	89	(20)
Alan K. Matsumoto
Joan M. Bathon
Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis	109	(12)
Barry Bresnihan
Leflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid Arthritis	121	(14)
Paul Emery
David L. Scott
Vibeke Strand
Matrix Metalloproteinase Inhibitors as Therapies for Rheumatoid Arthritis	135	(12)
Sean J. Wollaston
Kenneth C. Kalunian
Combination Disease-Modifying Anti-Rheumatic Drug (DMARD) Therapy	147	(12)
James R. O'Dell
Experimental Therapeutics for Rheumatoid Arthritis	159	(20)
Mark C. Genovese
William H. Robinson
II. Osteoarthritis
Jean-Pierre Pelletier
Johanne Martel-Pelletier
Slow-Acting Drugs for the Treatment of Osteoarthritis	179	(14)
Jean-Y ves Reginster
Roy D. Altman
Intra-Articular Therapy in Osteoarthritis	193	(8)
Boulos Haraoui
Jean-Pierre Raynauld
Promoting Articular Cartilage Repair	201	(14)
Joseph A. Buckwalter
James A. Martin
Using Molecular Markers to Monitor Osteoarthritis	215	(22)
Ivan G. Otterness
Mary J. Saltarelli
New Therapeutic Targets for Osteoarthritis: The Rewards of Research	237	(16)
Jean-Pierre Pelletier
Johanne Martel-Pelletier
Pamela Manning
Recent Developments in the Therapy of Osteoarthritis	253	(6)
Jean-Pierre Pelletier
Johanne Martel-Pelletier
III. Systemic Autoimmune Diseases
Gary M. Kammer
George C. Tsokos
Treatment of Systemic Lupus Erythematosus	259	(38)
Peter H. Schur
Gary M. Kammer
Treatment of the Antiphospholipid Syndrome	297	(18)
Joan T. Merrill
Treatment of Systemic Lupus Erythematosus by Blocking T-Cell Costimulation	315	(8)
David I. Daikh
David Wofsy
Current Management of Systemic Sclerosis	323	(14)
Clarence W. Legerton III
Richard M. Silver
Sjogren's Syndrome	337	(10)
Robert W. Hoffman
Eric L. Greidinger
Mixed Connective Tissue Disease	347	(12)
Robert W. Hoffman
Eric L. Greidinger
Vasculitis	359	(30)
Dimitrios Vassilopoulos
Leonard H. Calabrese
Treatment of Juvenile Rheumatoid Arthritis	389	(26)
Laura J. Mirkinson
Ildy M. Katona
Treatment of Inflammatory Myopathies	415	(20)
William R. Gilliland
Psoriatic Arthritis	435	(8)
Dimitrios T. Boumpas
Gabor G. Illei
Complement Inhibitors in Rheumatic Diseases	443	(10)
Sherry D. Fleming
George C. Tsokos
Hematopoietic Stem Celleraansplantation of Autoimmune Disease	453	(26)
Richard K. Burt
Ann E. Traynor
IV. Gene Therapy in Rheumatic Diseases
Steffen Gay
Vectors for Gene Delivery	479	(26)
Sandro Rusconi
Maurizio Ceppi
Gene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model	505	(16)
Jorg Schedel
Thomas Pap
Ulf Muller-Ladner
Renate E. Gay
Steffen Gay
Retroviral Transduction of Antigen-Specific CD4+T Cells for Local Delivery of Regulatory Molecules	521	(14)
Gina L. Costa
C. Garrison Fathman
Gene Transfer to Lymphocytes Targeting Cartilaginous Collagen Type II	535	(14)
Alexander E. Annenkov
Yuti Chernajovsky
Gene Therapy in Murine Arthritis: Cytokine-Directed Targeting	549	(16)
Wim B. van den Berg
Fons A. J. van de Loo
Modulation of the IkB Kinase/Nuclear Factor-kB Pathway by Gene Therapy	565	(10)
Paul P. Tak
Gary S. Firestein
Regulation of Apoptosis in Rheumatoid Synoviocytes	575	(8)
Kusuki Nishioka
Tetsuya Kobayashi
Gene Therapy for Arthritis: Conception, Consolidation, and Clinical Trial	583	(12)
Christopher H. Evans
Steven C. Ghivizzani
James H. Herndon
Mary C. Wasko
Paul D. Robbins
V. Other Rheumatic Disorders
George C. Tsokos
Recent Advances in the Pharmacotherapy of Spondyloarthropathies	595	(10)
Jurgen Braun
Joachim Sieper
Muhammad A. Khan
Modern Therapy of Crystal Arthropathies	605	(16)
Kanyakorn Jaovisidha
Ann K. Rosenthal
Treatment of Musculoskeletal Infections	621	(18)
Arthur Weinstein
Index	639