Modern Tools for the Synthesis of Complex Bioactive Molecules

by Cossy, Janine; Arseniyadis, Stellios

• ISBN13: 9780470616185
• ISBN10: 0470616180
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-10-09
• Publisher: Wiley

Summary

This book provides an overview of the new technologies that have revolutionized organic chemistry and allowed an easy access to very important complex bioactives. It is the only book of its kind assocating modern synthetic techniques and structurally complex bioactives, and includes some representative experimental procedures for particular methods. The synthesis of structurally complex molecules has become a real challenge among the synthetic community. In this context, the development of innovative methodologies allowing to control the exact connectivity of the atoms within a molecule, and to set the correct three-dimensional arrangement, have gained a great interest.

Author Biography

JANINE COSSY graduated from the University of Reims working under the supervision of Prof. Jean-Pierre Pète. After a postdoctoral stay with Prof. Barry Trost (1980-1982) at the University of Wisconsin, she returned to Reims where she became Director of Research of the CNRS in 1990. The same year, she moved to Paris to become Professor of Organic Chemistry at the Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI ParisTech). She has published over 380 articles and filed thirteen patents in the field of synthetic organic chemistry and natural product synthesis. She is Associate Editor at Organic Letters since 2005.

STELLIOS ARSENIYADIS was born in Greece in 1975. He studied chemistry at the Université Paris XI and received his PhD in 2002 from the Université Louis Pasteur (Strasbourg, France) working under the guidance of Dr. Charles Mioskowski. In 2001, he joined Rhodia ChiRex (Boston, USA) for an eighteen-month internship in collaboration with Prof. Stephen L. Buchwald (MIT, USA). He then spent a year as a postdoctoral fellow at Imperial College London (UK) working under the supervision of Prof. Alan C. Spivey, after which he joined Prof. K. C. Nicolaou's group at The Scripps Research Institute (La Jolla, USA) for an additional postdoc. In 2005, he was appointed by the CNRS as Chargé de Recherche in Prof. Janine Cossy's group. His research interests include the development of new synthetic tools and their application to the total synthesis of complex natural products.

Table of Contents

Foreword

Preface Contributors

C-H Functionalization: A New Strategy for the Synthesis of Biologically Active Natural Products

The Negishi Cross-Coupling in the Synthesis of Natural Products and Bioactive Molecules

Metal-Catalysed C-Heteroatom Cross-Coupling Reactions

Golden Opportunities in the Synthesis of Natural Products and Biologically Active Compounds

Metathesis-Based Synthesis of Complex Bioactives

Enantioselective Organocatalysis: A Powerful Tool for the Synthesis of Bioactive Molecules

Asymmetric Phase-Transfer Catalysis

Rearrangements in Natural Product Synthesis

Domino Reactions in the Enantioselective Synthesis of Bioactive Natural Products

Fluorous Linker-Facilitated Synthesis of Biologically Interesting Molecules

The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds

Synthetic Approaches to Bioactive Carbohydrates

Ammonium Ylides as Building Blocks for Alkaloid Synthesis

Precursor-Directed Biosynthesis of Polyketide and Non-Ribosomal Peptide Natural Products

Target-Oriented and Diversity-Oriented Organic Synthesis

DNA as a Tool for Molecular Discovery

Index

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