Modification of Radiation Response: Cytokines, Growth Factors, and Other Biological Targets

by Nieder, C.

• ISBN13: 9783540422310
• ISBN10: 3540422315
• Edition: 1st
• Format: Hardcover
• Copyright: 2003-05-01
• Publisher: SPRINGER

Summary

This book describes and summarizes the radiation responses of both normal and neoplastic tissues with a focus on rational strategies for the modification of these responses. Emerging data from molecular oncology and radiobiology that form the basis for a better understanding of radiation-induced reactions and key features of malignant growth are reviewed in depth. The book covers not only general principles of radiation-induced reactions but also a large number of preclinical and clinical data that will guide the reader through this complex and dynamic field and will provide valuable information for the development of further research projects. Many of the data reviewed in this book form a sound basis for further improvement of state-of-the art radiation therapy by integrating biological information into the process of treatment planning and delivery.

Table of Contents

Part I: Normal Tissues	1	(122)
The Potentional Role of Signaling Proteins in the Acceleration of Repopulating Normal and Malignant Tissues	3	(12)
Klaus-Rudiger Trott
Role of Radiation-Induced Signaling Proteins in the Response of Vascular and Connective Tissues	15	(14)
Hans-Peter Rodemann
Pathogenetic Mechanisms of Lung Fibrosis	29	(8)
Wolfgang Dorr
Thomas Herrmann
Strategies for Modification of the Radiation Response of the Lung	37	(12)
C. Nieder
Mechanisms and Modification of the Radiation Response of Gastrointestinal Organs	49	(24)
Martin Hauer-Jensen
Junru Wang
James W. Denham
Mechanisms and Modification of the Radiation Response of the Central Nervous System	73	(16)
Carsten Nieder
Nicolaus Andratschke
K. Kian Ang
Hematopoietic Tissue I: Response Modification by Erythropoietin	89	(14)
Jurgen Dunst
Hematopoietic Tissue II: Role of Colony-Stimulating Factors	103	(10)
Carsten Nieder
Branislav Jeremic
Thomas Licht
Frank B. Zimmermann
Oral Mucosa: Response Modification by Keratinocyte Growth Factor	113	(10)
Wolfgang Dorr
Part II: Malignancies	123	(152)
Role of Growth Factors in Tumor Growth and Progression of Gynecological Tumors	125	(14)
Jennifer F. De Los Santos
James M. Bonner
Shannon Goddard
Anthony W. Fyles
Growth Factor Expression in Central Nervous System Tumours	139	(8)
Carsten Nieder
Nicolaus Andratschke
Juergen Schlegel
Role of Growth Factors and Biological Response Modifiers in Lung, Head and Neck and Gastrointestinal Tumors	147	(10)
G. Stuben
Martin Stuschke
Role of Signaling Pathway Modification	157	(22)
Oliver Riesterer
Martin Pruschy
Stephan Bodis
Anti-VEGF Strategies in Combination with Radiotherapy	179	(10)
Daniel Zips
Michael Baumann
Role of Epidermal Growth Factor Receptor and Its Inhibition in Radiotherapy	189	(16)
Luka Milas
Z. Fan
Kathy A. Mason
K. Kian Ang
Enhancement of the Radiation Response with Interleukins and Interferons	205	(22)
Frank Lohr
Carsten Herskind
Jens Lohr
Frederik Wenz
Chuan-Yuan Li
Enhancement of Radiation Response with TNF/TRAIL	227	(14)
Anupama Munshi
Raymond E. Meyn
Role of Cyclooxygenase-2 (COX-2) and its Inhibition in Tumor Biology and Radiotherapy	241	(18)
Luka Milas
Kathy Mason
Zhongxing Liao
Uma Raju
Mira Milas
Amir Husain
K. Kian Ang
Ras Signaling and Its Inhibition with Farnesyltransferase Inhibitors: Effects on Radiation Resistance and the Tumor Microenvironment	259	(16)
Eric J. Bernhard
Anjali K. Gupta
Stephen M. Hahn
Ruth J. Muschel
W. Gillies McKenna
Subject Index	275	(4)
List of Contributors	279