Molecular Assembly in Natural and Engineered Systems

by Howorka

• ISBN13: 9780124159068
• ISBN10: 0124159060
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-10-26
• Publisher: Elsevier Science

Summary

This volume explores some of the most exciting recent advances in basic research on molecular assembly in natural and engineered systems and how this knowledge is leading to advances in the various fields. * This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Table of Contents

Contributors	p. ix
Preface	p. xi
Bacterial Microcompartments: Insights into the Structure, Mechanism, and Engineering Applications	p. 1
Introductio	p. 1
Bacterial Microcompartment Form and Function	p. 2
Shell Proteins: Structures and Mechanisms	p. 5
Higher-Level Organization	p. 9
Future Directions for Research and Design Applications	p. 11
Closing Remarks	p. 16
References	p. 16
Pili and Flagella: Biology, Structure, and Biotechnological Applications	p. 21
Introduction	p. 22
Pili in Gram-Negative Bacteria	p. 23
Pili in Gram-Positive Bacteria	p. 36
Surface Filaments in Archaea	p. 39
Flagella	p. 41
Applications	p. 47
References	p. 60
The Structure of Bacterial S-Layer Proteins	p. 73
Introduction	p. 74
Geobacillus stearothermophilus	p. 80
Clostridia	p. 88
Lactobacilli	p. 91
Bacillus anthracis	p. 95
Lysinibacillus sphaericus	p. 99
Corynebacterium glutamicum	p. 103
Deinococcus-Thermus	p. 104
S-Layers from Gram-Negative Bacteria	p. 110
Concluding Remarks	p. 117
References	p. 117
Spider Silk: Understanding the Structure-Function Relationship of a Natural Fiber	p. 131
Synopsis	p. 132
Spiders	p. 133
Nomenclature of Silk Types	p. 137
Set-up of Silk Proteins	p. 138
Major Ampullate Silk	p. 141
Flagelliform Silk	p. 161
Pseudoflagelliform Silk and Cribellate Silk	p. 163
Aciniform Silk	p. 165
Tubiliform Silk	p. 166
Egg Case Proteins	p. 167
Aggregate Silk	p. 168
Pyriform Silk	p. 168
Silk Summary	p. 169
Producing Recombinant Silk Proteins	p. 170
Future Outlook	p. 175
References	p. 177
Protein Modifications Giving Rise to Homo-oligomers	p. 187
Proteins as Building Blocks	p. 187
Hetero-Versus Homo-oligomers	p. 192
Symmetric Associations	p. 192
Lessons from Protein Crystallization	p. 197
The Analysis of Known Protein-Protein Contacts	p. 200
Self-assembly in Nature	p. 201
Self-assembling Protein Constructs	p. 202
Design of Protein-Protein Contacts	p. 210
Future Applications	p. 224
References	p. 225
Alpha-Helical Peptide Assemblies: Giving New function to Designed Structures	p. 231
Introduction	p. 232
Designing Discrete Helical Assemblies	p. 238
Designing Higher-Order Helical Assemblies	p. 258
Overview and Future Outlook	p. 268
References	p. 270
Nanobiotechnology with S-Layer Proteins as Building Blocks	p. 277
Introduction	p. 278
General Principles	p. 279
Assembly and Morphogenesis of S-Layers	p. 287
S-Layers for the Production of Ultrafiltration Membranes	p. 298
S-Layer as Matrix for the Immobilization of Functional Molecules and Nanoparticles	p. 302
S-Layer Fusion Proteins-Construction Principles and Applications	p. 306
S-Layers for Vaccine Development	p. 317
S-Layers as Supporting Structure for Functional Lipid Membranes	p. 320
S-Layers as Matrix for Biomineralization	p. 330
Conclusion and Perspectives	p. 331
References	p. 333
Viral Capsids as Self-Assembling Templates for New Materials	p. 353
Introduction	p. 354
Covalent Modification of Viral Capsids for Applications in Medical Imaging and Drug Delivery	p. 359
Viral Capsids as Templates for the Construction of Inorganic Materials	p. 370
Capsid-Based Materials for Optical and Catalytic Applications	p. 377
Summary and Future Challenges	p. 384
References	p. 386
Index	p. 393
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