Molecular Biology of Acute Lung Injury

by Wong, Hector R.; Shanley, Thomas P.

• ISBN13: 9780792374343
• ISBN10: 0792374347
• Format: Hardcover
• Copyright: 2001-10-01
• Publisher: Kluwer Academic Pub

Summary

Acute lung injury (ALI) impacts patient care in every ICU in the world. Our collective understanding of this condition has grown immensely over the past decade but morbidity and mortality remain unacceptably high. To enhance the understanding of clinicians and researchers, this book addresses the pathophysiology of acute lung injury from a molecular and cellular standpoint; includes animal models of acute lung injury and points to potential therapeutic advances based on scientific findings. It is a concise compendium of the multiple pathways, mechanisms and molecules involved in the pathophysiology of acute lung injury and is intended to help caregivers understand the process and thus care for patients more effectively.

Table of Contents

List of Contributors	vii
Preface	xi
Acknowledgements	xiii
Signal Transduction Pathways in Acute Lung Injury: NF-kB and AP-1	1	(16)
Thomas P. Shanley
Hector R. Wong
Innate Immune Mechanisms Triggering Lung Injury	17	(18)
Robert M. Strieter
John A. Belperio
David Kelley
Ammar Sakkour
Michael P. Keane
The Role of Chemokines in the Recruitment of Leukocytes During Lung Inflammation	35	(18)
Robert M. Strieter
John A. Belperio
David Kelley
Ammar Sakkour
Michael P. Keane
Regulation of Lung Immunity: Significance of the Cytokine Environment	53	(18)
Nicholas W. Lukacs
Theodore Standiford
Cory Hogaboam
Steven L. Kunkel
Role of Complement in Acute Lung Injury	71	(12)
Markus S. Huber-Lang
Peter A. Ward
Oxidant Stress in Acute Lung Injury	83	(18)
Jerry J. Zimmerman
Endogenous Nitric Oxide in Acute Lung Injury	101	(18)
Neil W. Kooy
Heme Oxygenase-1 in Acute Lung Injury	119	(14)
Jigme M. Sethi
Augustine M. K. Choi
Pulmonary Endothelial Surface Redox Acitivity: Roles in Propagation of and Protection from Injury	133	(16)
Marilyn P. Merker
Robert D. Bongard
Christopher A. Dawson
Mechanisms of Lung Epithelial Cell Injury by Pseudomonas Aeruginosa	149	(14)
Jeanine P. Wiener-Kronish
Dara Frank
Teiji Sawa
Alveolar Epithelial Repair in Acute Lung Injury	163	(14)
Thomas K. Geiser
Michael A. Matthay
Molecular Basis for Surfactant Function in ARDS	177	(16)
Liqian Zhang
Jeffrey A. Whitsett
Pulmonary Collectins and Defensins	193	(20)
Ann Marie LeVine
Lung Repair, Remodeling, and Fibrosis	213	(16)
Sujata Guharoy
Sem H. Phan
Apoptosis in Acute Lung Injury	229	(16)
Karine Faure
Benoit Guery
Jean Francois Pitter
Corticosteriod Treatment in Unresolving ARDS	245	(12)
G. Umberto Meduri
Anti-inflammatory Cytokines: Role in Regulation of Acute Lung Injury	257	(18)
Thomas P. Shanley
The Heat Shock Response and Heat Shock Protein 70: Cytopprotection in Acute Lung Injury	275	(14)
Hector R. Wong
Biotrauma: Signal Transduction and Gene Expression in the Lung	289	(38)
Claudia C. dos Santos
Mingyao Liu
Arthur S. Slutsky
Index	327