Molecular Biology of Alzheimer's Disease: Genes and Mechanisms Involved in Amyloid Generation

by Haass; Christian

• ISBN13: 9789057023811
• ISBN10: 9057023814
• eBook ISBN(s): 9781482283457
• Format: Hardcover
• Copyright: 1999-01-18
• Publisher: CRC Press

Summary

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

Table of Contents

Contributors	vii
Introduction	xi
A Pathology of Alzheimer's Disease
Amyloid Morphology and Pathology of Alzheimer's Disease	3	(14)
Haruyasu Yamaguchi
The Tau Proteins in Alzheimer's Disease	17	(30)
Roland Brandt
Jochen Eidenmuller
B The Genetics of Familial Alzheimer's Disease
Mutations in Three Genes are Associated with Early Onset Alzheimer's Disease	47	(28)
Paul E. Fraser
Peter H. St George-Hyslop
C Molecular and Cellular Biology of the β-Amyloid Precursor Protein and Amyloid β-Peptide
The Biological Activities and Function of the Amyloid Precursor Protein of Alzheimer's Disease	75	(20)
Gerd Multhaup
Colin L. Masters
Konrad Beyreuther
Roberto Cappai
Proteolytic Processing of the β-Amyloid Precursor Protein	95	(16)
Martin Citron
Dennis J. Selkoe
Biosynthesis of APP and Aβ: Multiple Pathways for the Generation of Intracellular Aβ	111	(22)
David G. Cook
Mark S. Forman
Abraham S.C. Chyung
Robert W. Doms
Virginia M.-Y. Lee
The Cell Biology of Amyloid Precursor Protein	133	(20)
Bart De Strooper
Fred Van Leuven
The Role of Amyloid β-Peptide Terminating at Amino Acid 42 in Early Onset Alzheimer's Disease	153	(10)
Steven G. Younkin
The Biophysics of Amyloid β-Protein Fibrillogenesis	163	(30)
David B. Teplow
D The Presenilin Genes
The Molecular Biology of Presenilin 1	193	(14)
Gopal Thinakaran
Sangram S. Sisodia
Molecular Biology of Presenilin 2	207	(12)
Wilma Wasco
Presenilin Proteins and their Role in Development and Notch Signaling	219	(16)
Ralf Baumeister
Christian Haass
The Processing of the Amyloid-Precursor-Protein (APP) in Presenilin-1 Deficient Neurons	235	(12)
Paul Saftig
Dieter Hartmann
Wim Annaert
Kathleen Craessaerts
Fred Van Leuven
Bart De Strooper
Presenilins and their Role in Apoptosis	247	(30)
Benjamin Wolozin
James Palacino
The Phosphorylation of Presenilin Proteins	277	(14)
Jochen Walter
Christian Haass
E Role of Risk Factors in Alzheimer's Disease
APOE and its Role in Late Onset Alzheimer's Disease	291	(18)
G. William Rebeck
F Transgenic Models for Alzheimer's Disease
Transgenic Animal Models in the Development of Therapeutic Strategies for Alzheimer's Disease	309	(18)
Matthias Staufenbiel
Bernd Sommer
Presenilins in Transgenic Mice	327	(4)
Karen Duff
Index	331