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Molecular Biology of B-Cell and T-Cell Development book cover, ISBN 9780896035362

Molecular Biology of B-Cell and T-Cell Development

by Monroe, John Gordon; Rothenberg, Ellen V.

ISBN13: 9780896035362
ISBN10: 0896035360
Format: Hardcover
Copyright: 1998-05-01
Publisher: Humana Pr Inc

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Summary

This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and receptors that mediate interactions between progenitor and cells comprising the stromal microenvironment, and demonstrate which are the triggering receptors, signaling pathways, and the developmental checkpoints controlling correct development of B- and T-cells. There is also a comparison of the vital roles of transcription factor combinations in establishing cell identity in the erythroid, myeloid, B, and T lineages. By juxtaposing the insights and approaches normally confined to either "immunology" or "hematology," this important book will help spark the growth of new research initiatives at the intersection of these two fields.

Table of Contents

Preface

v

(5)

Contributors

x

PART I: STEM CELLS AND LINEAGE COMMITMENT MODELS

3

(54)

CH. 1. Developmental Origins of Hematopoietic Stem Cells

3

(24)

Elaine Dzierzak

Alexander Medvinsky

CH. 2. Self-Renewal of Stem Cells: The Intrinsic Timetable Model

27

(14)

Peter Lansdorp

CH. 3. Transcription Factors Regulating Early Hematopoietic Development and Lineage Commitment

41

(16)

Stuart H. Orkin

PART II: INTRINSIC FACTORS REGULATING B AND T LYMPHOPOIESIS

57

(92)

CH. 4. The Ikaros Gene Family in Hemopoietic Differentiation

57

(14)

Nicole Avitahl

Aliki Nichogiannopoulou

Katia Georgopoulos

Susan Winandy

CH. 5. Transcriptional Control of B-Cell Differentiation by EBF and E2A

71

(12)

Mikael Sigvardsson

Rudolf Grosschedl

CH. 6. Role of the Transcription Factor BSAP (Pax-5) in B-Cell Development

83

(28)

Meinrad Busslinger

Stephen L. Nutt

CH. 7. The Role of PU.1 in the Regulation of Lymphoid and Myeloid Hematopoietic Progenitors

111

(16)

Edward W. Scott

CH. 8. Chromatin Structure and Lineage Determination

127

(22)

Dimitris Kioussis

Richard Festenstein

PART III: EXTRINSIC FACTORS REGULATING B AND T LYMPHOPOIESIS

149

(106)

CH. 9. The Role of Cytokines in Hematolymphoid Development

149

(28)

Tannishtha Reya

Simon R. Carding

CH. 10. Life/Death Decisions in B-Lymphocyte Precursors: A Role for Cytokines, Cell Interaction Molecules, and Hormones

177

(20)

Paul W. Kincade

Kay Medina

Glennda Smithson

Zhong Zheng

Kenji Oritani

Lisa Borghesi

Yoshio Yamashita

Kimberly Payne

Takaichi Shimozato

CH. 11. Regulation of Lymphocyte Development by Microenvironmental and Systemic Factors

197

(16)

Encarnacion Montecino-Rodriguez

Kenneth Dorshkind

CH. 12. Cytokines and Chemokines in T-Cell Development

213

(18)

Albert Zlotnik

Myriam Capone

Alain P. Vicari

CH. 13. Cytokine and Stromal Influences on Early B-Cell Development

231

(24)

Lisa J. Jarvis

Tucker W. LeBien

PART IV: COMMITMENT AND ORDERED PROGRESSION IN DEVELOPMENT OF LYMPHOID LINEAGES

255

(144)

CH. 14. Staging B-Cell Development and the Role of Ig Gene Arrangement in B-Lineage Progression

255

(12)

Richard R. Hardy

Susan Shinton

Robert Wasserman

Yue-Sheng Li

CH. 15. Lineage Relationships Between B Lymphocytes and Macrophages

267

(18)

Barbara L. Kee

Christopher J. Paige

CH. 16. TCR-Independent Development of Pluripotent T-Cell Precursors

285

(20)

Li Wu

Ferenc Livak

Howard T. Petrie

CH. 17. T-Cell Development from Hematopoietic Stem Cells

305

(32)

Koichi Akashi

Motonari Kondo

Annette M. Schlageter

Irving L. Weissman

CH. 18. Gene Regulation in T-Cell Lineage Committment

337

(30)

Ellen V. Rothenberg

CH. 19. The AlphaBeta/GammaDelta Lineage Decision: An Evaluation of the "T-Cell Receptor Determinant," "Progenitor Precommitment," or "Codeterminant" Models

367

(32)

Eric S. Hoffman

Lorena Passoni

Erastus C. Dudley

Michael Girardi

Adrian Hayday

PART V: SELECTION PROCESSES OPERATING DURING B-LYMPHOCYTE DEVELOPMENT

399

(50)

CH. 20. Structure and Function of the Pro-and Pre-B-Cell Receptors on B-Lymphoid Lineage Precursor Cells

399

(22)

Thomas H. Winkler

Fritz Melchers

CH. 21. Molecular Mechanisms Regulating Negative Selection in Immature-Stage B-Cells

421

(28)

Leslie B. King

Peter Sandel

Richard A. Sater

John G. Monroe

PART VI: SELECTION PROCESSES OPERATING DURING T-LYMPHOCYTE DEVELOPMENT

449

(56)

CH. 22. How Essential Is the Pre-T-Cell Receptor?

449

(16)

Jan Buer

Harald von Boehmer

CH. 23. Developmental Stage-Specific Responses to Ligation of CD3-Containing Complexes

465

(20)

Christiaan N. Levelt

CH. 24. The Molecular Basis of Thymocyte Positive Selection and CD4/CD8 Lineage Commitment

485

(20)

Cynthia J. Guidos

PART VII: CLINICAL APPLICATIONS OF HEMATOLYMPHOID DEVELOPMENT

505

(68)

CH. 25. Stem Cell Transplants for Hematopoietic Malignancies

505

(18)

Susan C. Guba

Bart Barlogie

CH. 26. Placental Blood: Immunology, Transplantation, and Gene Therapy

523

(22)

Anne F. Eder

Leslie E. Silberstein

CH. 27. Human Hematopoietic Stem Cells, Progenitors, and Peripheral Blood Lymphocytes as Targets for the Correction of Immune System Disorders via Gene Therapy

545

(28)

Karen E. Pollok

David A. Williams

Index

573

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