Molecular Biology of B-Cell and T-Cell Development

by Monroe, John Gordon; Rothenberg, Ellen V.

• ISBN13: 9780896035362
• ISBN10: 0896035360
• Format: Hardcover
• Copyright: 1998-05-01
• Publisher: Humana Pr Inc

Summary

This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and receptors that mediate interactions between progenitor and cells comprising the stromal microenvironment, and demonstrate which are the triggering receptors, signaling pathways, and the developmental checkpoints controlling correct development of B- and T-cells. There is also a comparison of the vital roles of transcription factor combinations in establishing cell identity in the erythroid, myeloid, B, and T lineages. By juxtaposing the insights and approaches normally confined to either "immunology" or "hematology," this important book will help spark the growth of new research initiatives at the intersection of these two fields.

Table of Contents

Preface	v	(5)
Contributors	x
PART I: STEM CELLS AND LINEAGE COMMITMENT MODELS	3	(54)
CH. 1. Developmental Origins of Hematopoietic Stem Cells	3	(24)
Elaine Dzierzak
Alexander Medvinsky
CH. 2. Self-Renewal of Stem Cells: The Intrinsic Timetable Model	27	(14)
Peter Lansdorp
CH. 3. Transcription Factors Regulating Early Hematopoietic Development and Lineage Commitment	41	(16)
Stuart H. Orkin
PART II: INTRINSIC FACTORS REGULATING B AND T LYMPHOPOIESIS	57	(92)
CH. 4. The Ikaros Gene Family in Hemopoietic Differentiation	57	(14)
Nicole Avitahl
Aliki Nichogiannopoulou
Katia Georgopoulos
Susan Winandy
CH. 5. Transcriptional Control of B-Cell Differentiation by EBF and E2A	71	(12)
Mikael Sigvardsson
Rudolf Grosschedl
CH. 6. Role of the Transcription Factor BSAP (Pax-5) in B-Cell Development	83	(28)
Meinrad Busslinger
Stephen L. Nutt
CH. 7. The Role of PU.1 in the Regulation of Lymphoid and Myeloid Hematopoietic Progenitors	111	(16)
Edward W. Scott
CH. 8. Chromatin Structure and Lineage Determination	127	(22)
Dimitris Kioussis
Richard Festenstein
PART III: EXTRINSIC FACTORS REGULATING B AND T LYMPHOPOIESIS	149	(106)
CH. 9. The Role of Cytokines in Hematolymphoid Development	149	(28)
Tannishtha Reya
Simon R. Carding
CH. 10. Life/Death Decisions in B-Lymphocyte Precursors: A Role for Cytokines, Cell Interaction Molecules, and Hormones	177	(20)
Paul W. Kincade
Kay Medina
Glennda Smithson
Zhong Zheng
Kenji Oritani
Lisa Borghesi
Yoshio Yamashita
Kimberly Payne
Takaichi Shimozato
CH. 11. Regulation of Lymphocyte Development by Microenvironmental and Systemic Factors	197	(16)
Encarnacion Montecino-Rodriguez
Kenneth Dorshkind
CH. 12. Cytokines and Chemokines in T-Cell Development	213	(18)
Albert Zlotnik
Myriam Capone
Alain P. Vicari
CH. 13. Cytokine and Stromal Influences on Early B-Cell Development	231	(24)
Lisa J. Jarvis
Tucker W. LeBien
PART IV: COMMITMENT AND ORDERED PROGRESSION IN DEVELOPMENT OF LYMPHOID LINEAGES	255	(144)
CH. 14. Staging B-Cell Development and the Role of Ig Gene Arrangement in B-Lineage Progression	255	(12)
Richard R. Hardy
Susan Shinton
Robert Wasserman
Yue-Sheng Li
CH. 15. Lineage Relationships Between B Lymphocytes and Macrophages	267	(18)
Barbara L. Kee
Christopher J. Paige
CH. 16. TCR-Independent Development of Pluripotent T-Cell Precursors	285	(20)
Li Wu
Ferenc Livak
Howard T. Petrie
CH. 17. T-Cell Development from Hematopoietic Stem Cells	305	(32)
Koichi Akashi
Motonari Kondo
Annette M. Schlageter
Irving L. Weissman
CH. 18. Gene Regulation in T-Cell Lineage Committment	337	(30)
Ellen V. Rothenberg
CH. 19. The AlphaBeta/GammaDelta Lineage Decision: An Evaluation of the "T-Cell Receptor Determinant," "Progenitor Precommitment," or "Codeterminant" Models	367	(32)
Eric S. Hoffman
Lorena Passoni
Erastus C. Dudley
Michael Girardi
Adrian Hayday
PART V: SELECTION PROCESSES OPERATING DURING B-LYMPHOCYTE DEVELOPMENT	399	(50)
CH. 20. Structure and Function of the Pro-and Pre-B-Cell Receptors on B-Lymphoid Lineage Precursor Cells	399	(22)
Thomas H. Winkler
Fritz Melchers
CH. 21. Molecular Mechanisms Regulating Negative Selection in Immature-Stage B-Cells	421	(28)
Leslie B. King
Peter Sandel
Richard A. Sater
John G. Monroe
PART VI: SELECTION PROCESSES OPERATING DURING T-LYMPHOCYTE DEVELOPMENT	449	(56)
CH. 22. How Essential Is the Pre-T-Cell Receptor?	449	(16)
Jan Buer
Harald von Boehmer
CH. 23. Developmental Stage-Specific Responses to Ligation of CD3-Containing Complexes	465	(20)
Christiaan N. Levelt
CH. 24. The Molecular Basis of Thymocyte Positive Selection and CD4/CD8 Lineage Commitment	485	(20)
Cynthia J. Guidos
PART VII: CLINICAL APPLICATIONS OF HEMATOLYMPHOID DEVELOPMENT	505	(68)
CH. 25. Stem Cell Transplants for Hematopoietic Malignancies	505	(18)
Susan C. Guba
Bart Barlogie
CH. 26. Placental Blood: Immunology, Transplantation, and Gene Therapy	523	(22)
Anne F. Eder
Leslie E. Silberstein
CH. 27. Human Hematopoietic Stem Cells, Progenitors, and Peripheral Blood Lymphocytes as Targets for the Correction of Immune System Disorders via Gene Therapy	545	(28)
Karen E. Pollok
David A. Williams
Index	573