Molecular Biology of Drug Addiction

by Maldonado, Rafael

• ISBN13: 9781588290601
• ISBN10: 1588290603
• Format: Hardcover
• Copyright: 2002-09-01
• Publisher: Humana Pr Inc

Summary

A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate the rewarding effects of drugs and analyze the genes involved in alcohol dependence.

Table of Contents

Preface	v
Contributors	ix
PART I. OPIOID ADDICTION
Molecular Mechanisms of Opioid Dependence by Using Knockout Mice	3	(24)
Brigitte L. Kieffer
Frederic Simonin
Molecular Genetic Approaches	27	(10)
Theo Mantamadiotis
Gunther Schutz
Rafael Maldonado
Opiate Addiction: Role of the cAMP Pathway and CREB	37	(8)
Lisa M. Monteggia
Eric J. Nestler
Different Intracellular Signaling Systems Involved in Opioid Tolerance/Dependence	45	(16)
Thomas Koch
Stefan Schulz
Volker Hollt
Inhibitors of Enkephalin Catabolism: New Therapeutic Tool in Opioid Dependence	61	(18)
Florence Noble
Bernard P. Roques
PART II. PSYCHOSTIMULANT ADDICTION
Recent Advances in the Molecular Mechanisms of Psychostimulant Abuse Using Knockout Mice	79	(28)
Cecile Spielewoy
Bruno Giros
Opioid Modulation of Psychomotor Stimulant Effects	107	(26)
Toni S. Shippenberg
Vladimir I. Chefer
Influence of Environmental and Hormonal Factors in Sensitivity to Psychostimulants	133	(28)
Michela Marinelli
Pier Vincenzo Piazza
Development and Expression of Behavioral Sensitization: Temporal Profile of Changes in Gene Expression	161	(12)
Peter W. Kalivas
PART III. CANNABINOID ADDICTION
New Advances in the Identification and Physiological Roles of the Components of the Endogenous Cannabinoid System	173	(26)
Ester Fride
Raphael Mechoulam
Integration of Molecular and Behavioral Approaches to Evaluate Cannabinoid Dependence	199	(22)
Dana E. Selley
Aron H. Lichtman
Billy R. Martin
Opioid System Involvement in Cannabinoid Tolerance and Dependence	221	(28)
Rafael Maldonado
PART IV. ALCOHOL AND NICOTINE ADDICTION
Current Strategies for Identifying Genes for Alcohol Sensitivity	249	(14)
John C. Crabbe
Genetic Basis of Ethanol Reward	263	(32)
Christopher L. Cunningham
Tamara J. Phillips
Behavioral and Molecular Aspects of Alcohol Craving and Relapse	295	(20)
Rainer Spanagel
Molecular and Behavioral Aspects of Nicotine Dependence and Reward	315	(24)
Emilio Merlo Pich
Christian Heidbreder
Manolo Mugnaini
Vincenzo Teneggi
Index	339