Molecular Biology of Protein Folding, Part A

by Conn

• ISBN13: 9780123745941
• ISBN10: 0123745942
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-12-08
• Publisher: Elsevier Science

Summary

The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of the expression of newly translated proteins. These volumes (Parts A & B) address this important topic. As a volume in Progress in Nucleic Acid Research and Molecular Biology, this book provides the latest information on the expanding research being conducted on protein folding. Illustrates how ubiquitin domain proteins are an ideal model system for experimental and computational studies of protein folding. Discusses structural wrapping and its importance in the contexts of network centrality, molecular disease, drug discovery and molecular theranostic engineering. Chapters written by international authors in engineering, biochemistry, physics, and computer science.

Table of Contents

Stability and Design of [alpha]-Helical Peptides	p. 1
Introduction	p. 2
Design of Peptide Helices	p. 7
Helix-Coil Theory	p. 15
Forces Affecting [alpha]-Helix Stability	p. 25
References	p. 38
Folding and Wrapping Soluble Proteins: Exploring the Molecular Basis of Cooperativity and Aggregation	p. 53
Folding, Cooperativity, and Wrapping of Soluble Proteins: An Overview	p. 54
Wrapping the Folded Structure	p. 57
Exploring the Molecular Basis of Folding Cooperativity	p. 62
Protein Under-Wrapping, Misfolding, and Aggregation	p. 80
References	p. 85
Rescuing Proteins of Low Kinetic Stability by Chaperones and Natural Ligands: Phenylketonuria, a Case Study	p. 89
Introduction	p. 90
Protein Folding	p. 93
Misfolding	p. 100
Ligand Binding	p. 110
Strategies to Correct Misfolding	p. 116
Concluding Remarks	p. 123
References	p. 124
The Endoplasmic Reticulum: Crossroads for Newly Synthesized Polypeptide Chains	p. 135
Protein Translocation and Maturation in the Mammalian ER	p. 136
Substrate Recognition and Dislocation into the Cytosol for ERAD	p. 152
References	p. 163
All-Atom Protein Folding with Free-Energy Forcefields	p. 181
Introduction	p. 182
Protein Structure and Folding	p. 186
Kinetic Folding Methods	p. 199
Free-Energy Forcefields and Simulation Methods	p. 205
Free-Energy Protein Folding	p. 216
Summary	p. 242
Outlook	p. 246
References	p. 247
Folding Considerations for Therapeutic Protein Formulations	p. 255
Introduction	p. 256
Folding and Stability of Therapeutic Proteins	p. 257
Case Study: Rational Formulation Development of Human Recombinant Factor VIII	p. 266
References	p. 268
Index	p. 271
Table of Contents provided by Ingram. All Rights Reserved.