Molecular and Cellular Basis of Inflammation

by Serhan, Charles N.; Ward, Peter A.

• ISBN13: 9780896035959
• ISBN10: 0896035956
• Format: Hardcover
• Copyright: 1999-01-01
• Publisher: Humana Pr Inc

Summary

This collection of cutting-edge reviews of the molecular and cellular bases of inflammatory processes makes an important and timely contribution to the search for new antiinflammatory agents. The book authoritatively reviews the role of protein and lipid mediators in inflammation, cellular processes of importance in the initiation and determination of inflammation, signal transduction events of interest in the development of potential new therapeutic targets, and drug design issues in inflammation therapeutics. In addition, several chapters summarize state-of-the-art findings in disease processes where inflammation plays a critical role. Reflecting the work of leading researchers in molecular biology, biochemistry, pharmacology, immunology, and pathobiology, Molecular and Cellular Basis of Inflammation establishes new basic concepts in the elucidation of molecular mechanisms in inflammation.

Table of Contents

Preface	v	(5)
Contributors	x
CH. 1. Role of Complement in Endothelial Cell Activation	3	(26)
Peter A. Ward
Hedwig S. Murphy
CH. 2. Angiogenesis	29	(22)
Douglas A. Arenberg
Robert M. Streiter
CH. 3. Update on Arachidonic Acid Cascade: Leukotrienes and Lipoxins in Disease Models	51	(42)
Josper Z. Haeggstrom
Charles N. Serhan
CH. 4. Mutagenesis Studies of Mammalian Lipoxygenases	93	(16)
Olof Radmark
CH. 5. Lipid-Mediator-Deficient Mice in Models of Inflammation	109	(18)
Colin D. Funk
CH. 6. Isoprostanes in the Assessment of Oxidant Stress In Vivo	127	(14)
Muredach P. Reilly
Domenico Paratico
Paul Lanken
Norman Delanty
Joshua Rockach
John Lawson
Garrett A. FitzGerald
CH. 7. Isoprostanes as Markers of Lipid Peroxidation in Atherosclerosis	141	(24)
L. Jackson Roberts II
Jason D. Morrow
CH. 8. Structure and Regulation of NADPH Oxidase of Phagocytic Leukocytes: Insights from Chronic Granulomatous Disease	165	(28)
Paul G. Heyworth
John T. Curnutte
John A. Badwey
CH. 9. Recruitment of Gamma/Delta T-Cells and Other T-Cell Subsets to Sites of Inflammation	193	(22)
Mark A. Jutila
CH. 10. The N-Formyl Peptide Receptor: Structure, Signaling, and Disease	215	(32)
John S. Mills
Heini M. Minettinen
Michael J. Valses
Algirdas J. Jesaitis
CH. 11. Pathobiology of Neutrophil Interactions with Polarized Columnar Epithelia	247	(12)
James L. Madara
CH. 12. Adenosine and Its Receptors During Inflammation	259	(16)
Bruce N. Cronstein
CH. 13. Quantitative Studies of the Lipid Mediators of Inflammation Using Liquid Chromatography-Electrospray Mass Spectrometry	275	(14)
Pierre Borgeat
Serge Picard
Nancy Dallaire
Marc Pouliot
Mark E. Surette
CH. 14. Molecular Biology of Autoimmune Arthritis	289	(20)
Edward F. Rosloniec
Leslie R. Ballou
Rajendra Raghow
Karen A. Hasty
Andrew H. Kang
CH. 15. Lupus Erythematosus: The Role of Adhesion Molecules and Local Mediators	309	(16)
H. Michael Belmont
Steven B. Abramson
Index	325