Molecular Dissection of Complex Traits

by Paterson; Andrew H.

• ISBN13: 9780849376863
• ISBN10: 0849376866
• eBook ISBN(s): 9780429525414
• Format: Hardcover
• Copyright: 1997-08-29
• Publisher: CRC Press
• More Book Details

Summary

In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in this field within the context of their historical origins. Leading authorities address central themes in analysis of complex phenotypes, and case histories of important work in this burgeoning field are presented by the principal investigators.The book is divided into three sections:

Table of Contents

INTRODUCTION	1	(12)
Chapter 1 Of Blending, Beans, and Bristles: The Foundations of QTL Mapping	1	(12)
Andrew H. Paterson
PART I. FUNDAMENTAL PRINCIPLES	13	(174)
Chapter 2 Molecular Tools for the Study of Complex Traits	13	(18)
Mark D. Burow
Thomas K. Blake
Chapter 3 Mapping Quantitative Trait Loci in Experimental Populations	31	(12)
Gary A. Churchill
Rebecca W. Doerge
Chapter 4 Computational Tools for Study of Complex Traits	43	(38)
Ben-Hui Liu
Chapter 5 QTL Mapping in Outbred Pedigrees	81	(14)
Claire G. Williams
Chapter 6 Mapping QTLs in Autopolyploids	95	(8)
Sin-Chieh Liu
Yann-Rong Lin
James E. Irvine
Andrew H. Paterson
Chapter 7 QTL Analysis under Linkage Equilibrium	103	(16)
Jeremy F. Taylor
Joao L. Rocha
Chapter 8 Molecular Analysis of Epistasis	119	(12)
Zhikang Li
Chapter 9 QTL Mapping in DNA Marker-Assisted Plant and Animal Improvement	131	(14)
Andrew H. Paterson
Chapter 10 QTL Analyses: Power, Precision, and Accuracy	145	(18)
William D. Beavis
Chapter 11 High-Resolution Mapping of QTLs	163	(12)
Andrew H. Paterson
Chapter 12 Compilation and Distribution of Data on Complex Traits	175	(12)
Douglas W. Bigwood
PART II. CASE HISTORIES	187	(80)
Chapter 13 Case History in Plant Domestication: Sorghum, An Example of Cereal Evolution	187	(10)
Andrew H. Paterson
Keith F. Schertz
Yann-rong Lin
Zhikang Li
Chapter 14 Case History in Crop Improvement: Yield Heterosis in Maize	197	(10)
Charles W. Stuber
Chapter 15 Case History in Germplasm Introgression: Tomato Genetics and Breeding Using Nearly Isogenic Introgression Lines Derived from Wild Species	207	(12)
Dani Zamir
Yuval Eshed
Chapter 16 Case History in Genetics of Long-Lived Plants: Molecular Approaches to Domestication of a Fast-Growing Forest Tree: Populus	219	(10)
H. D. Bradshaw, Jr.
Chapter 17 Case History in Animal Improvement: Mapping Complex Traits in Ruminants	229	(12)
Michel Georges
Chapter 18 Case History in Animal Improvement: Genetic Mapping of QTLs for Growth and Fatness in the Pig	241	(14)
Leif Andersson
Kjell Andersson
Lena Andersson-Eklund
Inger Edfors-Lilja
Hans Ellegren
Chris S. Haley
Ingemar Hansson
Maria Johansson Moller
Sara A. Knott
Kerstin Lundstrom
Lena Marklund
Chapter 19 Case History in Humans: Mapping QTLs for Complex Traits in Humans	255	(12)
Hakan Sakul
Lon R. Cardon
PART III. SOCIAL IMPACT OF QTL MAPPING	267	(22)
Chapter 20 From Malthus to Mapping: Prospects for the Utilization of Genome Analysis to Enhance the World Food Supply	267	(12)
Jinhua Xiao
Susan R. McCouch
Chapter 21 Ethical Consequences of Mapping QTLs for Complex Human Traits	279	(10)
John C. Crabbe
John K. Belknap
EPILOGUE	289	(6)
Chapter 22 Prospects for Cloning the Genetic Determinants of QTLs	289	(6)
Andrew H. Paterson
INDEX	295