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9780521460675

Molecular Endocrinology of Cancer

by
  • ISBN13:

    9780521460675

  • ISBN10:

    0521460670

  • Format: Hardcover
  • Copyright: 1996-01-26
  • Publisher: Cambridge University Press

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Summary

One third of human cancers have a hormonal basis. Breast cancer, the most common cancer of women, is increasing in many countries, as is prostate cancer, the second most common cancer of men. Concurrently, molecular biology has refined the definition of hormones to include the interaction between tumor cells and both locally and distantly secreted factors. This volume in the series Cancer: Clinical Science in Practice considers aspects of hormonal cancer, including the molecular basis for the autocrine and paracrine regulation of cancer, molecular strategies for cancer detection, strategies in limiting the epidemic of hormonally related cancers, and new treatment approaches.

Table of Contents

Part I. The Regulation of Cancer: 1. Growth factor receptor family and their ligands and their role in human cancers
2. The fibroblast growth factor family and their receptors
3. The biological role of transforming growth factor-ß
in cancer development
4. Bombesin and its receptor
5. Gonadotrophin-releasing hormone and its receptor
6. The metalloproteinases and their inhibitors
7. Steroid hormones and their receptors
8. Cytokines
Part II. The Prevention of Endocrine Dependent Tumours: 9. Familial cancer
10. Diet
Part III. The Biological Basis for the Treatment of Endocrine Dependent Tumours: 11. Breast cancer: new biological approaches to treatment
12. The biological basis for the treatment of prostate cancer
13. Carcinoid tumours
Part IV. Complications of Cancer Treatment: 14. Hypercalcaemia
15. The anaemia of cancer.

Supplemental Materials

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