Molecular and Genetic Basis of Renal Disease

by Mount, David B.

• ISBN13: 9781416002529
• ISBN10: 1416002529
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-10-01
• Publisher: SAUNDERS W B CO

Summary

This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the neprhon as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.

Table of Contents

The Tools Of Molecular Nephrology

The impact of Genetics and Genomics on Renal Science and Renal Medicine

Manipulation of the Mouse Genome: Studying Renal Function and Disease

Cardiorenal Physiology of the Mouse: From Loss of Genome to Gain of Phenome

Murine Modeling of Kidney Development

Genetic Disorders Of Renal Growth And Structure

Hereditary Disorders of Renal and Urogenital Development

Autosomal Polycystic Kidney Disease (ADPKD)

Autosomal Recessive Polycystic Kidney Disease (ARPKD)

Pathogenesis of Nephronophthisis and Medullary Cystic Kidney Disease Thomas Benzing

Genetic Disorders Of Renal Function

Hereditary Nephroses

Molecular and Genetic Basis of Alport Syndrome

Nail-Patella Syndrome

Primary Hyperoxalurias: Molecular and Clinical Insights

Fabry Disease

Hereditary Disorders of the Proximal Tubule

Hereditary Disorders of the Thick Ascending Limb and Distal Convoluted Tubule

Hereditary Disorders of Distal Nephron Sodium and Potassium Transport

Hereditary Renal Tubular Acidosis

Hereditary Causes of Nephrogenic Diabetes Insipidus

Genetic Disorders of Calcium and Phosphate Homeostasis

Genetics and Renal Pathophysiology of Essential Hypertension

Acquired And Polygenic Renal Disease

Molecular Mechanisms of Proteinuria

Diabetic Nephropathy

Pathogenesis of HIV-Associated Nephropathy

Pathogenesis of Paraproteinemic Renal Disease

Preeclampsia, Sharon Maynard

Molecular Insights into the Thrombotic Microangiopathies

IgA nephropathy

Glomerulonephritis Caused by Antineutrophil Cytoplasmic autoantibodies (ANCA)

Systemic Lupus erythematosus and the Kidney

Acute Tubular Necrosis

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