Molecular Genetics of Liver Neoplasia

by Wang, Xin Wei; Grisham, Joe W.; Thorgeirsson, Snorri S.

• ISBN13: 9781441960818
• ISBN10: 1441960813
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-11-08
• Publisher: Springer Verlag

Summary

Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor's aggressiveness at the time of diagnosis and the lack of effective therapy.

Table of Contents

Introduction
Biology of Hepatocellular Carcinoma: Past, Present and Beyond	p. 3
Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum	p. 19
Liver Cancer Development and Pathogenesis
Pathology of Hepatocellular Carcinoma	p. 37
Genetics and Epidemiology of Liver Cancer
Epidemiology of Hepatocellular Carcinoma	p. 51
Genetics and Epidemiology of Cholangiocarcinoma	p. 75
Molecular Basis of Cancer Susceptibility
Signaling Pathways in Viral Related Pre-neoplastic Liver Disease and Hepatocellular Carcinoma	p. 103
Epigenetic Effects of Persistent Hepatitis C Virus Infection and Hepatocellular Carcinoma	p. 129
DNA Methylation Status in Chronic Liver Disease and Hepatocellular Carcinoma	p. 147
Animal Models
Transgenic and Knockout Mouse Models of Liver Cancer	p. 163
Mosaic Cancer Mouse Models and Functional Oncogenomics in Hepatocellular Carcinoma	p. 189
The Zebrafish Model for Liver Carcinogenesis	p. 197
Global Gene Expression Profiling of Human Liver Cancer
Integrative and Functional Genomics of HCC	p. 221
Molecular Signatures of Hepatocellular Carcinoma Metastasis	p. 241
Gene Mutations and Transcriptomic Profiles Associated to Specific Subtypes of Hepatocellular Tumors	p. 259
Cancer Stem Cells
Cancer Stem Cells and Liver Cancer	p. 279
Heterogeneity of Liver Cancer Stem Cells	p. 301
Cancer Stem Cells in Liver Carcinoma	p. 319
Liver Cancer Genetics in the Clinic
Molecular Signaling in Hepatocellular Carcinoma	p. 337
Molecular Events on Metastasis of Hepatocellular Carcinoma	p. 349
Molecular Pathogenesis of Hepatocellular Carcinoma	p. 373
Subject Index	p. 397
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