Molecular Microbiology of Heavy Metals

by Nies, Dietrich H.; Silver, Simon

• ISBN13: 9783540697701
• ISBN10: 3540697705
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-07-04
• Publisher: Springer Verlag

Summary

All forms of life depend on a variety of heavy metal ions. Nearly one-third of all gene products require a metal ion for proper folding or function. However, even metals generally regarded as non-poisonous are toxic at higher concentrations, including the essential ones. Thus, sensitive regulation of metal uptake, storage, allocation and detoxification is needed to maintain cellular homeostasis of heavy metal ions.Molecular Microbiology of Heavy Metals includes chapters on allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. Also discussed are metal bioreporters for the nanomolar range of concentration and tools to address the metallome. Chapters in the second part cover specific metals such as Fe, Mn, Cu, Ni, Co, Zn and Mo as key nutrient elements and Ag, As, Cd, Hg and Cr as toxic elements.

Table of Contents

Understanding how cells allocate metals	p. 3
Metalloregulators : arbiters of metal sufficiency	p. 37
Transcriptomic responses of bacterial cells to sublethal metal ion stress	p. 73
Bacterial transition metal homeostasis
Biosensing of heavy metals	p. 143
A glossary of microanalytical tools to assess the metallome	p. 159
Acquisition of iron by bacteria	p. 189
New transport deals for old iron	p. 221
Manganese : uptake, biological function, and role in virulence	p. 235
How bacteria handle copper	p. 259
Microbial physiology of nickel and cobalt	p. 287
Zinc, cadmium, and lead resistance and homeostasis	p. 321
Microbiology of the toxic noble metal silver	p. 343
Mercury microbiology : resistance systems, environmental aspects, methylation, and human health	p. 357
Arsenic metabolism in prokaryotic and eukaryotic microbes	p. 371
Reduction and efflux of chromate by bacteria	p. 407
Molybdate and tungstate : uptake, homeostasis, cofactors, and enzymes	p. 421
Table of Contents provided by Blackwell. All Rights Reserved.