Molecular Neurobiology for the Clinician

by Charney, Dennis S.

• ISBN13: 9781585621132
• ISBN10: 1585621137
• Edition: 1st
• Format: Paperback
• Copyright: 2003-05-01
• Publisher: AMERICAN PSYCHIATRIC PUBLISHING INC

Summary

In this authoritative volume you'll find today's most important molecular neurobiological advances and their relevance to clinicians treating patients with mental illness. Molecular Neurobiology for the Clinician, Review of Psychiatry, Volume 22, will update you on the latest findings-and their impact on psychiatry. You'll learn about Discoveries with the potential to revolutionize your clinical approach by changing the ways in which you diagnose and treat patients The effects on psychiatry of advances in the molecular basis of neuronal network function, particularly in relation to abnormalities in cognitive and emotional regulation, and the identification of novel molecular targets for drug development How to apply these discoveries to diagnosing and treating major psychiatric disorders, including childhood- and adolescent-onset disorders, schizophrenia, drug addiction, and severe mood and anxiety disorders Molecular Neurobiology for the Clinicianis an outstanding compilation of the best research by top names in the field. Psychiatrists, psychologists, psychiatric residents, and graduate students in neuroscience, psychiatry, and psychology will gain knowledge, understanding, and techniques for better diagnosis and treatment.

Author Biography

Dennis S. Charney, M.D., is Chief of the Mood and Anxiety Disorders Program, and Chief of the Experimental Therapeutics and Pathophysiology Branch, at the National Institute of Mental Health in Bethesda, Maryland.

Table of Contents

Contributors	vii
Introduction to the Review of Psychiatry Series	ix
John M. Oldham
Michelle B. Riba
Preface	xiii
Dennis S. Charney
Molecular Neurobiology of Childhood- and Adolescent-Onset Psychiatric Disorders	1	(62)
Jeremy Veenstra-VanderWeele
Edwin H. Cook Jr.
Chromosomal and Relatively Simple Genetic Disorders	3	(5)
Complex Disorders	8	(26)
Complex Genetic Disorders With Variable-Onset Psychiatric Phenotypes	34	(5)
Summary	39	(2)
References	41	(22)
Molecular Genetics: A Role in Diagnosis and Treatment of Psychiatric Disorders?	63	(12)
Francis J. McMahon
Genetic Basis of Major Mental Illness	63	(1)
Common Alleles for Common Diseases	64	(3)
The Common Disease--Common Variant Hypothesis	67	(1)
Translating Genetic Findings Into Clinical Practice	68	(1)
Specific Applications of Genetic Findings	69	(3)
Genetic Attributable Risk	72	(1)
Conclusion: The Psychiatrist as Interpreter of Genetic Findings	73	(1)
References	73	(2)
Molecular Neurobiology and Schizophrenia: Implications for Etiology and Treatment	75	(32)
Andrew R. Gilbert
David W. Volk
David A. Lewis
Etiological Factors and Schizophrenia	76	(5)
Genetic Variation and Schizophrenia	81	(6)
Molecular Systems and Schizophrenia: Molecular Alterations in the Context of Neural Circuitry	87	(11)
Implications for Understanding the Etiopathogenesis of Schizophrenia	98	(2)
References	100	(7)
Molecular Mechanisms of Drug Addiction	107	(16)
Eric J. Nestler
Role of CREB in Drug Addiction	108	(5)
Role of ΔFosB in Drug Addiction	113	(4)
Conclusion	117	(1)
References	118	(5)
Cellular Neurobiology of Severe Mood and Anxiety Disorders: Implications for Development of Novel Therapeutics	123	(78)
Todd D. Gould
Neil A. Gray
Husseini K. Manji
Signaling Networks:	126	(1)
Neurobiology of Mood Disorders	127	(33)
Neurobiology of Anxiety Disorders	160	(15)
Conclusion	175	(3)
References	178	(23)
Appendix 1: Knockout Mouse Studies That Have Been Used to Test Anxiety-Like Behaviors	201	(10)
Appendix 2: Potential Targets for the Development of New Treatments for Mood and Anxiety Disorders	211	(18)
Index	229