Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, Second Edition

by Nestler, Eric; Hyman, Steven; Malenka, Robert

• ISBN13: 9780071481274
• ISBN10: 0071481273
• Edition: 2nd
• Format: Paperback
• Copyright: 2008-11-17
• Publisher: McGraw-Hill Professional

Summary

Turn to the classic primer of molecular neuroscience for a complete understanding of nervous system function and it's relationship to human neurologic disordersMolecular Neuropharmacologyoffers a clear, thorough explanation of the molecular functioning of the nervous system in normal and disease states. More than three hundred concept-clarifying full-color illustrations along with didactic text boxes provide an in-depth understanding of nerve cell receptors, their effectors and second messenger targets, and the molecular genetics that are often impacted by these systems. You will also learn how malfunction of these molecular systems relates to human disease and the corresponding medical treatment.Molecular Neuropharmacologyis the most relevant, well-written resource available to help you make the connection between neuropharmacology and clinical neuroscience.FEATURES: Numerous figures and didactic boxes to help you understand and remember complex subject matter for efficient, on-the-spot review All-inclusive, high-yield coverage, including: The fundamentals of neuropharmacology Neural substrates of drug action The neuorpharmacology of specific functions and disorders-encompassing control of movement, mood and emotion, memory and dementia, and other vital areas NEW! A streamlined redesign that makes the book even more practical and accessible than ever NEW! More illustrations-all 300 now in full color!

Author Biography

Eric J. Nestler, MD, is professor and chairman of the Department of Psychiatry and the Center for Basic Neuroscience at the Southwestern Medical School, Graduate School of Biomedical Science in Dallas, Texas.

Stephen E. Hyman, MD, is provost of Harvard University and professor of neurobiology at Harvard Medical School.

Robert C. Malenka, MD, Ph.D., is Pritzker Professor of Psychiatry & Behavioral Sciences at Stanford University.

Table of Contents

Contributing Authors to the Second Edition	p. ix
Contributing Authors to the First Edition	p. xi
Preface	p. xiii
Fundamentals of Neuropharmacology
Basic Principles of Neuropharmacology	p. 3
Cellular Basis of Communication	p. 16
Synaptic Transmission	p. 55
Signal Transduction in the Brain	p. 74
Neural Substrates of Drug Action
Excitatory and Inhibitory Amino Acids	p. 117
Widely Projecting Systems: Monoamines, Acetylcholine, and Orexin	p. 145
Neuropeptides	p. 181
Atypical Neurotransmitters	p. 199
Neuropharmacology of Neural Systems and Disorders
Autonomic Nervous System	p. 227
Neural and Neuroendocrine Control of the Internal Milieu	p. 246
Pain and Inflammation	p. 269
Sleep and Arousal	p. 289
Higher Cognitive Function and Behavioral Control	p. 313
Mood and Emotion	p. 335
Reinforcement and Addictive Disorders	p. 364
Schizophrenia and Other Psychoses	p. 389
Neurodegeneration	p. 409
Seizure Disorders	p. 443
Stroke and Migraine	p. 457
Index	p. 475
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