Molecular Pathogenesis of Periodontal Disease

by Genco, Robert J.; Hamada, Shigeyuki; Lehner, Thomas

• ISBN13: 9781555810757
• ISBN10: 1555810756
• Format: Hardcover
• Copyright: 1994-08-01
• Publisher: Amer Society for Microbiology

Table of Contents

Contributors
Preface
Acknowledgments
Introduction
Epidemiology of Subgingival Bacterial Pathogens in Periodontal Disease	p. 3
Porphyromonas gingivalis Fimbriae: Structure, Function, and Insertional Inactivation Mutants	p. 13
Molecular Genetic Approaches for Identifying Virulence Factors of Porphyromonas gingivalis	p. 25
DNA Fingerprinting of Porphyromonas gingivalis by Arbitrarily Primed PCR	p. 33
Relationship between Iron Availability and Periodontal Disease Associated with Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans	p. 47
Invasion of Cultured Epithelial Cells by Periodontopathogens	p. 57
Molecular Biology of Actinobacillus actinomycetemcomitans Leukotoxin	p. 69
Bacterial Polysaccharides as Microbial Virulence Factors	p. 83
Campylobacter rectus Toxins	p. 93
Bacterial Endotoxic Substances and Their Effects on Host Cells	p. 105
CD14 and Lipopolysaccharide Binding Protein Control Host Responses to Bacterial Lipopolysaccharide	p. 119
Cytokine Networks and Immunoglobulin Synthesis in Inflamed Gingival Tissues	p. 135
Modulatory Role of T Lymphocytes in Periodontal Inflammation	p. 147
Human Immune Responses in Periodontal Disease: Analysis of Severe Combined Immunodeficient Mice Reconstituted with Lymphocytes from Patients with Localized Juvenile Periodontitis	p. 159
Mechanisms of Regulation of Bone Formation by Proinflammatory Cytokines	p. 171
Regulation of Chronic Inflammation	p. 183
Host-Mediated Extracellular Matrix Destruction by Metalloproteinases	p. 191
Role of Prostaglandins in High-Risk Periodontitis Patients	p. 203
Leukocyte Adhesion Molecules CD11/CD18 and Their Role in Periodontal Diseases	p. 215
Role of the Extracellular Matrix in Inflammation	p. 235
The Platelet as an Inflammatory Cell in Periodontal Diseases: Interactions with Porphyromonas gingivalis	p. 247
Role of Antibodies in Periodontopathic Bacterial Infections	p. 257
Immunization with Porphyromonas gingivalis Fimbriae and a Synthetic Fimbrial Peptide	p. 267
T-Cell and B-Cell Epitope Mapping and Construction of Peptide Vaccines	p. 279
Regulation of Immunoglobulin A Responses for Oral Mucosal Immunity	p. 293
New Ideas about Neutrophil Antimicrobial Mechanisms: Antibiotic Peptides, Postphagocytic Protein Processing, and Cystosolic Defense Factors	p. 321
Antimicrobial Dysfunction in Localized Juvenile Periodontitis Neutrophils	p. 337
Neutrophil Receptors: N-Formyl-l-Methionyl-l-Leucyl-l-Phenylalanine and Interleukin-8	p. 351
The OmpA Protein of Actinobacillus actinomycetemcomitans: Physicochemical and Immunologic Features	p. 363
Genetics of Early-Onset Periodontal Diseases	p. 373
Principles of Regenerative Therapy	p. 393
Differential Regulation of Periodontal Ligament Cell Activities by Platelet-Derived Growth Factor, Insulin-Like Growth Factor I, and Epidermal Growth Factor	p. 403
Polypeptide Growth Factors: Molecular Mediators of Tissue Repair	p. 415
Role of Osteogenic (Bone Morphogenetic) Protein and Platelet-Derived Growth Factor in Periodontal Wound Healing	p. 427
Extracellular Matrix and Bone Morphogenetic Proteins: Molecular Approaches to Dentin and Periodontal Repair	p. 439
Index	p. 449
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