Molecular Pathogenesis of Virus Infections

by Edited by P. Digard , A. A. Nash , R. E. Randall

• ISBN13: 9780521832489
• ISBN10: 0521832489
• Edition: 1st
• Format: Hardcover
• Copyright: 2005-05-23
• Publisher: Cambridge University Press

Summary

Virus and prion diseases remain a major public health threat, in both developed and developing countries. The worldwide HIV pandemic is but one example of a newly emerged virus disease; other potential threats come from exotic viruses such as SARS, Ebola and Hantaan viruses. Older human viruses such as influenza, papilloma, herpes and the hepatitis viruses still cause major health problems. Furthermore, as well as causing acute infections, some viruses may also establish persistent infections which can lead to the development of chronic diseases, including cancer. This symposium book covers central factors that influence the pathogenicity of virus and prion infections. Topics range from innate and adaptive immune responses and virus evasion of host defences to details of selected virus­host interactions, including those involving dengue virus, HIV, influenza viruses, coronaviruses, hepatitis C virus, herpesviruses, papillomaviruses, African swine fever virus and poxviruses.

Table of Contents

Contributors	vii
Adaptive immune responses	1	(14)
J. L. Whitton
T-cell responses and dengue haemorrhagic fever	15	(8)
G. Screaton
J. Mongkolsapaya
The immune response to human immunodeficiency virus type 1 (HIV-1)	23	(68)
E. Turnbull
P. Borrow
Persistent RNA virus infections	91	(18)
C. M. Dixon
L. Breakwell
G. Barry
J. K. Fazakerley
Pathogenesis of Ebola and Marburg viruses	109	(16)
A. L. Hartman
J. S. Towner
S. Nichol
Molecular approaches to the pathogenesis of feline coronaviruses	125	(12)
C. Dye
S. Siddell
The Transmissible spongiform encephalopathies	137	(22)
J. C. Manson
R. M. Barron
Influenza virus Pathogenicity	159	(20)
R. G. Webster
A. S. Lipatov
E. Hoffmann
RNAi as an antiviral mechanism and therapeutic approach	179	(24)
R. P. van Rij
R. Andino
Neurons and host immunity conspire to maintain herpes simplex virus in a latent state	203	(12)
M. L. Freeman
V. Decman
R. L. Hendricks
Hepatitis C virus disruption of interferon signalling pathways and evasion of innate intracellular antiviral defences	215	(20)
S. M. Lemon
K. Li
Human papillomaviruses and their effects on cell cycle control and apoptosis	235	(18)
L. Gray
C. Jolly
C. S. Herrington
Intracellular antiviral defence mechanisms: the power of interferon-regulated restriction factors	253	(16)
O. Haller
F. Weber
G. Kochs
Secreted tumour necrosis factor inhibitors encoded by poxviruses	269	(22)
M. B. Ruiz-Arguello
A. Alejo
A. Alcami
Evasion of host defence systems by African swine fever virus	291	(28)
L. K. Dixon
Murid herpesvirus 4 as a model for gammaherpesvirus pathogenesis	319	(22)
J. P. Stewart
D. Hughes
L. Roaden
B. Ebrahimi
Index	341