Molecular Pathology of Gynecologic Cancer

by Giordano, Antonio; Bovicelli, Allesandro, M.D., Ph.D.; Kurman, Robert J.

• ISBN13: 9781588294531
• ISBN10: 1588294536
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-04-30
• Publisher: Humana Pr Inc

Summary

Molecular Pathology of Gynecologic Cancer focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors' hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients. This new volume in Humana's Current Clinical Oncology'„¢ series will be necessary reading for clinicians and experimental researchers alike.

Table of Contents

Preface	p. vii
Contributors	p. xi
Color Plates	p. xiii
Introduction
The Cell Cycle and the Molecular Biology of Cancer	p. 3
Ovarian Cancer
Ovarian Serous Carcinogenesis: A Proposed Model	p. 17
Molecular Markers in Epithelial Ovarian Cancer	p. 29
Endometrial Cancer
Introduction to Endometrial Cancer	p. 51
Endometrial Carcinogenesis: An Integrated, Molecular, Histological, and Functional Model of a Dualistic Disease	p. 73
Endometrial Carcinoma-Molecular Genetic Aspects	p. 91
Cervical Cancer
Natural History of HPV Infection in Adolescents and Relationship to Cervical Cancer	p. 103
Molecular Genetics of Cervical Cancer	p. 113
Prevention and Treatment of Cervical Cancer by Vaccination	p. 125
Gestational Trophoblastic Disease
Pathogenesis of Gestational Trophoblastic Lesions	p. 157
Hereditary Issues in Gynecological Cancer
Hereditary Issues in Ovarian Cancer	p. 169
Hereditary Factors in Endometrial Cancer	p. 195
The Multidisciplinary Therapeutic Approach to Gynecological Cancer in the New Millenium
The Holistic Approach to Female Cancer Patients	p. 219
Index	p. 223
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