Molecular Physiology of Growth

by Edited by P. T. Loughna , J. M. Pell

• ISBN13: 9780521114530
• ISBN10: 0521114535
• Edition: 1st
• Format: Paperback
• Copyright: 2009-06-25
• Publisher: Cambridge University Press

Summary

In this diverse synthesis of recent research, the regulation of growth in response to environmental and genetic stimuli is discussed in reference to tissues and cells, as well as the whole animal. Many issues are addressed in detail, including how hormones and growth factors regulate animal growth in the developing embryo and what processes at the molecular level determine the growth patterns of different tissues. The text draws contrasts between regulation in fetal and adult tissues, and among different tissues such as the CNS, bone and muscle. Functional chapters focus on the molecular links between mechanical tension and muscle growth, for example, while other chapters review the roles of specific molecules such as growth hormone.

Table of Contents

Role of growth hormone in growth regulation

Insulin-like growth factor-1 and its binding proteins: role in postnatal growth

Growth factor interactions in epiphyseal chondrogenesis

Developmental changes in the CNS response to injury: growth factor and matrix interactions

The role of transforming factor Ã? during cardiovascular development

Tenascin: an extracellular matrix protein associated with bone growth

Compartmentation of protein synthesis, mRNA targeting and c-myc expression during mucle hypertrophy and growth

The role of mechanical tension in regulating muscle growth and phenotype

The prenatal influence on postnatal muscle growth

Genomic imprinting and intrauterine growth retardation

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