Molecular Physiology of Growth

by Edited by P. T. Loughna , J. M. Pell

• ISBN13: 9780521471107
• ISBN10: 0521471109
• Format: Hardcover
• Copyright: 1997-01-13
• Publisher: Cambridge University Press

Summary

How do hormones and growth factors regulate animal growth in the developing embryo and after injury? What processes at the molecular level determine the growth patterns of different tissues? In this diverse synthesis of recent research the regulation of growth in response to environmental and genetic stimuli is discussed at the level of the animal, tissues and cells. Contrasts are drawn between regulation in foetal and adult tissues, and in different tissues such as the CNS, bone and muscle. Functional chapters focus on the molecular links between mechanical tension and muscle growth, for example, while other chapters review the roles of specific molecules such as growth hormone. This state of the art review will be of significant interest to graduate students and research scientists in the fields of animal growth, endocrinology and cell biology.

Table of Contents

List of Contributors	ix
The role of growth hormone in growth regulation	1	(12)
D.J. FLINT
K. AKINSANYA
P.J. CRILLY
P. JOHNSTON
D. WYNICK
Insulin-like growth factor-I and its binding proteins: role in post-natal growth	13	(22)
J.M. PELL
J. GLASSFORD
Growth factor interactions in epiphyseal chondrogenesis	35	(14)
D.J. HILL
Developmental changes in the CNS response to injury: growth factor and matrix interactions	49	(20)
A. LOGAN
The role of Transforming growth factor B during cardiovascular development	69	(18)
M.C. DICKSON
J.S. MARTIN
R.J. AKHURST
Tenascin: an extracellular matrix protein associated with bone growth	87	(12)
E.J. MACKIE
S. RAMSEY
Compartmentation of protein synthesis, mRNA targeting and c-myc expression during muscle hypertrophy and growth	99	(20)
J. HESKETH
The role of mechanical tension in regulating muscle growth and phenotype	119	(16)
P.T. LOUGHNA
C. BROWNSON
The pre-natal influence on post-natal muscle growth	135	(16)
N.C. STICKLAND
C.M. DWYER
Genomic imprinting and intrauterine growth retardation	151	(12)
G.E. MOORE
P.R. BENNETT
Z. ALI
R. U. KHAN
J. I. VAUGHAN
Index	163