Molecular System Bioenergetics Energy for Life

by Saks, Valdur

• ISBN13: 9783527317875
• ISBN10: 3527317872
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-10-29
• Publisher: Wiley-VCH

Summary

In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.

Author Biography

Valdur Saks is Professor of Bioenergetics and Biochemistry at the University of Grenoble, France, and Head of the Laboratory of Bioenergetics at the National Institute of Chemical and Biological Physics in Tallinn, Estonia. A graduate of Moscow University, he was the long-time head of the Laboratory of Cardiac Bioenergetics in Moscow, Russia, before taking up his present positions. Professor Saks has authored over 220 scientific publications and has received numerous scientific awards, including the USSR State Prize in Science and the Internatinoal "Research and Development" Award sponsored by the U.N. and UNICEF. He is a member of the International Society for Heart Research and of the American Physiological and Biophysical Societies.

Table of Contents

Preface

List of Contributors

Introduction: From the Discovery of Biological Oxidation to Molecular System Bioenergetics (Valdur Saks

References

Molecular System Bioenergetics: Basic Principles, Organization, and Dynamics of Cellular Energetics

Cellular Energy Metabolism and Integrated Oxidative Phosphorylation

Abstract

Introduction

Membrane Transport and Initial Activation

Cytosolic Pathway

Mitochondrial Transport and Metabolism

Respiratory Chain and Oxidative Phosphorylation

Electron Supply

Reducing Power Shuttling Across the Mitochondrial Membrane

Electron Transfer in the Respiratory Chain: Prominent Role of Complex I in the Regulation of the Nature of Substrate

Modulation of Oxidative Phosphorylation by Respiratory Chain Slipping and Proton Leak

The Nature of Cellular Substrates Interferes with the Metabolic Consequences of Uncoupling

Dynamic Supramolecular Arrangement of Respiratory Chain and Regulation of Oxidative Phosphorylation

References

Organization and Regulation of Mitochondrial Oxidative Phosphorylation

Abstract

Introduction

Oxidative Phosphorylation and the Chemiosmotic Theory

The Various Mechanisms of Energy Waste

Mechanisms of Coupling in Proton Pumps

Oxidative Phosphorylation Control and Regulation

Supramolecular Organization of the Respiratory Chain

Conclusions

References

Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation, and Metabolic Channeling

Abstract

Introduction

Theoretical Basis of Cellular Metabolism and Bioenergetics

Compartmentalized Energy Transfer and Metabolic Sensing

On the Network Properties of Mitochondria

Abstract

Introduction

The Study of (Sub)Cellular Networks and the Emerging View of Cells as Dynamic Mass Energy Information Networks

Mitochondrial Morphodynamics

The Key Role of Inner and Outer Membrane Ion Channels on Mitochondrial Network Dynamics

Mitochondrial Network Behavior Associated with Intracellular Signaling

Mitochondria as a Network of Coupled Oscillators

Discussion

Concluding Remarks

References

Structural Organization and Dynamics of Mitochondria in the Cells in Vivo

Abstract

Introduction

Intracellular Organization of Mitochondria

Mitochondrial Dynamics: Regulation of Mitochondrial Morphology

Mitochondrial Dynamics: Mitochondrial Movement (Motility) in the Cell

Concluding Remarks

References

Energy Transfer Networks, Metabolic Feedback Regulation, and Modeling of Cellular Energetics

Mitochondrial VDAC and Its Complexes

Abstract

The Role of VDAC in Controlling the Interaction of Mitochondria with the Cytosol

Molecular Structure and Membrane Topology of VDAC

VDAC Conductance

The Physiological Signi.cance of VDAC Voltage Gating

VDAC Isoforms and Functions

Mitochondria and Apoptosis

VDAC and ANT May Form the Mitochondrial Permeability Transition Pore

Accessory MPT Pore Subunits

ANT Knockout Studies

The Role of VDAC in Organizing Kinas

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