Molecular Targeting and Signal Transduction

by Kumar, Rakesh

• ISBN13: 9781402078224
• ISBN10: 1402078226
• Format: Hardcover
• Copyright: 2004-05-01
• Publisher: Kluwer Academic Pub

Summary

Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

Table of Contents

Biology of the Epidermal Growth Factor Receptor Family	1	(14)
Christopher J. Barnes
Rakesh Kumar
Integrin Signaling in Cancer	15	(18)
Hira Lal Goel
Lucia R. Languino
Regulators of Vascular Endothelial Growth Factor Expression in Cancer	33	(26)
Oliver Stoeltzing
Lee M. Ellis
Integrin-Linked Kinase (ILK) in Combination Molecular Targeting	59	(18)
Lincoln A. Edwards
Jennifer A. Shabbits
Marcel Bally
Shoukat Dedhar
p21-Activated Kinase 1: An Emerging Therapeutic Target	77	(12)
Ratna K. Vadlamudi
Rakesh Kumar
Basis and Importance of Src as a Target in Cancer	89	(32)
Victor A. Levin
Therapeutic Targeting of the Receptor Tyrosine Kinase Met	121	(18)
Martin Sattler
Patrick C. Ma
Ravi Salgia
Nuclear Factor -κB Activation Mediates Cellular Transformation, Proliferation, Invasion, Angiogenesis and Metastasis of Cancer	139	(36)
Shishir Shishodia
Bharat B. Aggarwal
The p53 Pathway: Targets for the Development of Novel Cancer Therapeutics	175	(14)
Shulin Wang
Wafik S. El-Deiry
Runx Protein Signaling in Human Cancers	189	(28)
Ian Anglin
Antonio Passaniti
Signal Transduction Mediated by Cyclin D1: From Mitogens to Cell Proliferation: A Molecular Target with Therapeutic Potential	217	(22)
Chenguang Wang
Zhiping Li
Maofu Fu
Toula Bouras
Richard G. Pestell
Signal Transduction Pathways in Bcr-Abl Transformed Cells	239	(32)
Ralph Arlinghaus
Tong Sun
Estrogen Receptors and Anti-Estrogen Therapies	271	(22)
Lakjaya Buluwela
Demetra Constantinidou
Joanna Pike
Simak Ali
Targeting Endothelin Axis in Cancer	293	(22)
Anna Bagnato
Pier Giorgio Natali
km23: A Novel TGFβ Signaling Target Altered in Ovarian Cancer	315	(14)
Wei Ding
Kathleen M. Mulder
Index	329