Multimodal Concepts for Integration of Cytotoxic Drugs

by Mehta, Minesh P.; Mehta, M. P.; Nieder, C.

• ISBN13: 9783540256557
• ISBN10: 3540256555
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-06-30
• Publisher: Springer Verlag

Summary

Over recent decades, combined modality treatment has drastically improved the cure rates for various malignant tumors. Further progress is expected through the design of sound combinations involving recently developed drugs. The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. The text, written by acknowledged experts, is specifically designed to be accessible to professionals from the various disciplines involved in multidisciplinary cancer care and to residents in radiation oncology training programs.

Author Biography

J. Martin Brown, PhD, is a Professor of Radiation Oncology at Stanford University. He was president of the Radiation Research Society and member of several program and award committees of the American Association for Cancer Research. Dr. Brown is currently the senior editor for biology for the International Journal of Radiation Oncology Biology Physics. He has received a number of awards, including an NIH M.E.R.I.T. Award, the Research Award from the Radiation Research Society, the 1999 Cain Memorial Award from the American Association for Cancer Research, the 1999 ASTRO Gold Medal, and the Weiss Medal from the Association for Radiation Research. Minesh P. Mehta, MD, is Professor and Chairman of the Department of Human Oncology, University of Wisconsin Medical School, Madison. He is the Chairman of the Radiation Therapy Oncology Group Brain Tumor Committee and is on the editorial board of the Journal of Neuro-Oncology and the International Journal of Cancer Research.Carsten Nieder, MD, is head of the Radiation Oncology Section of the Multidisciplinary Cancer Center and deputy head of the Stereotactic Central Nervous System Radiotherapy program, Klinikum rechts der Isar, Munich. He has received a 2-year research scholarship from the Mildred Scheel Foundation and the Hanns Langendorff Award 2003. Dr. Nieder is on the editorial board of Reviews of Recent Randomized Trials.

Table of Contents

Preclinical Part	1	(162)
Biological Basis of Combined Radio- and Chemotherapy	3	(16)
Claus Belka
Carsten Nieder
Michael Molls
Combinations of Antimetabolites and Ionizing Radiation	19	(16)
Hiroshi Harada
Keiko Shibuya
Masahiro Hiraoka
Combinations of Taxanes and Ionizing Radiation	35	(18)
Luka Milas
Kathryn A. Mason
Zhongxing Liao
Kian K. Ang
Combinations of Topoisomerase Inhibitors and Ionizing Radiation	53	(14)
Michael Bastasch
Hak Choy
Combinations of Hypoxia-Targeting Compounds and Radiation-Activated Prodrugs with Ionizing Radiation	67	(26)
G-One Ahn
J. Martin Brown
Combinations of Platinum Compounds and Ionizing Radiation	93	(10)
Carsten Nieder
Florian Lordick
Combinations of Cytotoxic Drugs, Ionizing Radiation and Angiogenesis Inhibitors	103	(12)
Carsten Nieder
Nicolaus H. Andratschke
Combinations of Cytotoxic Drugs, Ionizing Radiation and EGFR Inhibitors	115	(12)
Guido Lammering
Combinations of Cytotoxic Drugs, Ionizing Radiation and Mammalian Target of Rapamycin (mTOR) Inhibitors	127	(12)
Jann N. Sarkaria
Combinations of Ionizing Radiation and Other Sensitizing Agents	139	(12)
Minesh P. Mehta
Radiotherapy and Tumor-Targeted Drug Delivery	151	(12)
Zhaozhong Han
Ghazal Hariri
Dennis E. Hallahan
Clinical Part	163	(178)
Applications in Malignant Brain Tumors	165	(22)
Carsten Nieder
Mark R. Gilbert
Applications in Head and Neck Cancer	187	(10)
Deepak Khuntia
Anne M. Traynor
Paul M. Harari
Jean Bourhis
Applications in Esophageal and Gastric Cancer	197	(18)
Frank Zimmermann
Bjorn L. D. M. Brucher
Novel Chemoradiation in Localized Pancreatic Cancer: Clinical Studies	215	(16)
Christopher H. Crane
Gauri Varadhachary
Peter W. T. Pisters
Douglas B. Evans
Robert A. Wolff
Applications in Lung Cancer	231	(20)
Jochen Fleckenstein
Christian Rube
Integration of Radiation Therapy and Systemic Therapy for Breast Cancer	251	(16)
Seungtaek Choi
Howard D. Thames
Thomas A. Buchholz
Applications in Rectal and Anal Cancer	267	(18)
Claus Rodel
Rolf Sauer
Concomitant Radiation and Chemotherapy in Muscle-Invasive Bladder Cancer	285	(18)
Jurgen Dunst
Claus Rodel
Anthony Zietman
Applications to Gynecological Cancers	303	(14)
Anthony W. Fyles
Michael Milosevic
Amit Oza
Early and Late Treatment-Induced Toxicity	317	(16)
Wolfgang Dorr
Dorothea Riesenbeck
Carsten Nieder
Feasibility of Combined Chemo- and Radiation Treatment in Elderly/Comorbid Patients	333	(8)
Hans Geinitz
Subject Index	341	(4)
List of Contributors	345