Multiple Myeloma : An Issue of Hematology - Oncology Clinics

by Anderson, Kenneth C.

• ISBN13: 9781416050827
• ISBN10: 1416050825
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-12-10
• Publisher: Elsevier Science Health Science div

Summary

Although treatable with conventional and high dose therapies, multiple myeloma (MM) remains incurable. However, recent advances in oncogenomics, coupled with increased understanding of the role of the bone marrow (BM) microenvironment in MM pathogenesis, has provided the basis for a new treatment paradigm targeting the tumor cell in the BM milieu to overcome conventional drug resistance and improve patient outcome. This text will first describe advances in molecular pathogenesis of MM due to cutting edge comparative genomic hybridization, gene microarray, and proteomic profiling of MM cells. The molecular basis for the growth, survival, drug resistance, and migration of MM cells, including extracellular matrix proteins, BM stromal cells, and cytokines in the BM milieu, will next be delineated using both laboratory and animal model systems. Importantly, recent advances in the pathogenesis of bone disease in MM will be described. These preclinical studies all will set the stage for the bench to bedside translation of scientific advances to the clinic to improve patient outcome. The clinical approach to patients with plasma cell dyscrasias has been transformed in the past 5 years. There are now uniform definitions of monoclonal gammopathy of unclear significance and improved predictors of who will develop MM. Biologically-based prognostic factors form the basis for new staging systems predictive of patient outcome. The approach to the patient with newly diagnosed, relapsed, and relapsed refractory MM has been transformed, with improved overall and extent of response as well as progression-free and overall survival, in both transplant candidates and elderly patients. Novel targeted therapies and immune-based strategies hold great promise to enhance treatment options even further. Finally our ability to identify, prophylax, and treat complications of MM and its treatment has advanced in a parallel fashion. Myeloma therefore represents a novel treatment paradigm targeting the tumor cell, tumor host interaction, and tumor microenvironment which can serve as a model to outcome in patients with other hematologic cancers and solid tumors as well.

Table of Contents

Preface	p. xiii
Molecular Pathogenesis of Multiple Myeloma	p. 985
The Role of the Bone Marrow Microenvironment in the Pathophysiology of Myeloma and Its Significance in the Development of More Effective Therapies	p. 1007
Pathophysiology of Multiple Myeloma Bone Disease	p. 1035
Mouse Models of Human Myeloma	p. 1051
Preclinical Studies of Novel Targeted Therapies	p. 1071
Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma	p. 1093
Prognostic Factors and Staging in Multiple Myeloma	p. 1115
Management of Newly Diagnosed Myeloma	p. 1141
Role of Stem Cell Transplantation	p. 1157
Management of Relapsed and Relapsed Refractory Myeloma	p. 1175
Immune Therapies	p. 1217
Complications of Multiple Myeloma	p. 1231
Complications of Myeloma Therapy	p. 1247
Index	p. 1275
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