Multiple Myeloma and Related Disorders

by Gahrton; Gosta

• ISBN13: 9780340810101
• ISBN10: 0340810106
• Format: Hardcover
• Copyright: 2004-04-30
• Publisher: CRC Press

Summary

During the last decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes and to gain information about gene expression. Microarray is in its early stage but already there have been pattern descriptions that may have prognostic implications. The impact of chromosomal abnormalities is now clearer than before, and the complicated interaction between the stroma cells, the myeloma cells, and numerous cytokines and their receptors has been better explained. Attempts have been made to utilize this new knowledge to develop targeted therapy and although results are still modest, improvements have been obtained with thalidomide and analogues, as well as with proteasome inhibitors. It is therefore highly appropriate that this new comp

Author Biography

Brian G. M. Durie is Attending Physician in the Department of Hematology and Oncology, Cedars-Sinai Comprehensive Cancer Center; and Senior Research Advisor for Hematologic Malignancies at Salick Health Care Inc., Los Angeles, CA, USA.

Table of Contents

List of contributors	v
Preface	ix
List of abbreviations	x
Notes on reference annotation	xiv
PART 1 HISTORY AND EPIDEMIOLOGY	1	(26)
History of multiple myeloma	3	(12)
Robert A. Kyle
David P. Steensma
Epidemiology and etiology of plasma cell neoplasms	15	(12)
Daniel E. Bergsagel
P. Leif Bergsagel
PART 2 BIOLOGY AND PATHOPHYSIOLOGY	27	(62)
The immune system in myeloma	29	(17)
Douglas E. Joshua
P. Joy Ho
John Gibson
Ross D. Brown
Molecular biology and cytogenetics	46	(12)
Johannes Drach
Jutta Ackermann
Sonja Seidl
Hannes Kaufmann
Biology of the malignant plasma cell	58	(16)
Federico Caligaris-Cappio
Pathophysiology of myeloma bone disease	74	(15)
Babatunde O. Oyajobi
Gregory R. Mundy
PART 3 CLINICAL FEATURES, DIAGNOSIS, AND INVESTIGATION	89	(112)
Clinical features	91	(11)
Dietrich Peest
Hematologic investigations: morphologic and phenotypic features of myeloma marrow diagnosis	102	(23)
Thomas M. Grogan
Deborah Gelbspan
Lisa Rimsza
Biochemical and immunological investigations	125	(30)
Joanna M. Sheldon
Pamela G. Riches
The role of imaging in multiple myeloma	155	(9)
Brian G.M. Durie
Innovative approaches for diagnosis and monitoring	164	(15)
Faith E. Davies
Gareth J. Morgan
Multiple myeloma: differential diagnosis and prognosis	179	(22)
Jesus F. San Miguel
Ramon Garcia-Sanz
PART 4 TREATMENT OF MYELOMA	201	(116)
Principles of management	203	(17)
Diana M. Samson
Chemotherapy, steroids, and interferon	220	(21)
Diana M. Samson
Radiotherapy	241	(9)
Deborah A. Frassica
Maria C. Jacobs
Autologous stem cell transplantation	250	(10)
Jean-Luc Harousseau
Michel Attal
Allogeneic transplantation and treatment with donor lymphocytes	260	(15)
Gosta Gahrton
Per Ljungman
Supportive care	275	(17)
Heinz Ludwig
Johannes Drach
Biological basis of therapy: new molecular targets	292	(13)
Terry H. Landowski
William S. Dalton
Immunotherapeutic approaches	305	(12)
Hakan Mellstedt
PART 5 COMPLICATIONS	317	(50)
Management of bone disease	319	(20)
Eugene V. McCloskey
Management of myeloma patients with renal failure	339	(11)
Joan Blade
Laura Rosinol
Neurologic aspects of monoclonal gammopathy of undetermined significance, multiple myeloma, and related disorders	350	(17)
Robert A. Kyle
Angela Dispenzieri
PART 6 RELATED DISORDERS	367	(86)
Monoclonal gammopathies of undetermined significance: the transition from MGUS to myeloma	369	(10)
John A. Lust
Kathleen A. Donovan
Philip R. Greipp
Solitary bone and extramedullary plasmacytoma	379	(9)
Meletios A. Dimopoulos
Lia A. Moulopoulos
Plasma cell leukaemia	388	(12)
Xavier Leleu
Ibrahim Yakoub-Agha
Thierry Facon
Al amyloidosis	400	(20)
Raymond L. Comenzo
Heavy-chain diseases	420	(9)
Jean-Paul Fermand
Jean-Claude Brouet
Waldenstrom's disease	429	(24)
Giampaolo Merlini
Steven P. Treon
Index	453