Myasthenia Gravis and Related Disorders

by Kaminski, Henry J.

• ISBN13: 9781588290588
• ISBN10: 1588290581
• eBook ISBN(s): 9781592593415
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-10-01
• Publisher: Springer Verlag

Summary

An international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromytonia and Lambert-Eaton syndrome. For the clinician, the book describes the wide range of signs and symptoms that make these diseases difficult to diagnose, review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatments now emerging. For the basic scientist, the text illuminates neuromuscular structure and function, describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis), and illuminates the autoimmune pathogenesis.

Table of Contents

Preface	v
Contributors	ix
Neuromuscular Junction Physiology and Pathophysiology	1	(14)
Robert L. Ruff
Acetylcholine Receptor Structure	15	(38)
Jon M. Lindstrom
Immunopathogenesis of Myasthenia Gravis	53	(40)
Bianca M. Conti-Fine
Brenda Diethelm-Okita
Norma Ostlie
Wei Wang
Monica Milani
Clinical Presentation and Epidemiology of Myasthenia Gravis	93	(22)
Jan B.M. Kuks
Hans J.G.H. Oosterhuis
Ocular Myasthenia	115	(14)
Robert B. Daroff
Thymoma-Associated Myasthenia Gravis	129	(20)
Alexander Marx
Philipp Stroebel
Electrodiagnosis of Neuromuscular Junction Disorders	149	(28)
Bashar Katirji
Specific Antibodies in the Diagnosis and Management of Autoimmune Disorders of Neuromuscular Transmission and Related Diseases	177	(20)
Mark A. Agius
David P. Richman
Angela Vincent
Treatment of Myasthenia Gravis	197	(26)
Henry J. Kaminski
Neurocritical Care of Myasthenia Gravis Crisis	223	(12)
Jose Americo M. Fernandes Filho
Jose I. Suarez
Thymectomy	235	(34)
Alfred Jaretzki III
Lambert-Eaton Syndrome	269	(24)
C. Michel Harper
Vanda A. Lennon
Acquired Neuromyotonia	293	(16)
Ian Hart
Angela Vincent
Congenital Myasthenic Syndromes	309	(18)
Suraj A. Muley
Christopher M. Gomez
Toxic Neuromuscular Transmission Disorders	327	(28)
James F. Howard, Jr.
Psychological and Social Consequences of Myasthenia Gravis	355	(18)
Robert H. Paul
James M. Gilchrist
Appendix: Myasthenia Gravis Foundation of America Recommendations for Clinical Research Standards	373	(8)
Index	381