Myelodysplastic Syndromes: Clinical and Biological Advances

by Edited by Peter L. Greenberg

• ISBN13: 9780521496681
• ISBN10: 0521496683
• Format: Hardcover
• Copyright: 2006-01-09
• Publisher: Cambridge University Press

Summary

As the major current reference on all aspects of the clinical classification underlying pathogenetic mechanisms and treatment of the myelodysplastic syndromes, Myelodysplastic Syndromes stands out as the definitive text on the genetics, pathophysiology, and clinical management of this wide range of syndromes. Authored by international experts, this book provides a state-of-the-art update of the current status and recent advances in the field. The chapters cover all aspects of the myelodysplastic syndromes, from an in-depth analysis of the multifactorial nature of this disease, including a careful assessment of stromal, immunological and stem cell abnormalities, to a review of recent molecular and cytogenetic discoveries and insights. This book will be a valuable resource to clinicians and researchers who wish to learn more about myelodysplastic syndromes.

Table of Contents

List of contributors	ix
Preface	xi
Clinical and prognostic characterization of myelodysplastic syndromes	1	(32)
Peter L. Greenberg
Morphologic classifications of myelodysplastic syndromes: French--American--British (FAB) and World Health Organization (WHO)	33	(30)
Richard D. Brunning
Pathogenetic mechanisms underlying myelodysplastic syndromes	63	(32)
Peter L. Greenberg
Cytogenetic abnormalities in myelodysplastic syndromes	95	(34)
Harold J. Olney
Michelle M. Le Beau
Molecular mechanisms and gene expression patterns in myelodysplastic syndromes	129	(18)
Wolf-Karsten Hofmann
H. Phillip Koef er
Immunologic mechanisms and treatment of myelodysplastic syndromes	147	(26)
A. John Barrett
Elaine Sloand
Neal S. Young
Biologically targeted therapies for myelodysplastic syndromes	173	(36)
Andrew J. Buresh
Alan F. List
Supportive care in myelodysplastic syndromes: hemopoietic cytokine and iron chelation therapy	209	(34)
Jason Gotlib
Peter L. Greenberg
Hematopoietic cell transplantation for myelodysplastic syndromes	243	(20)
H. Joachim Deeg
Bart Scott
Health-related quality of life for those with myelodysplastic syndrome: conceptualization, measurement, and implications for research and practice	263	(34)
Mary Laudon Thomas
Index	297