Myocardial Ischemia and Preconditioning

by Dhalla, Naranjan S.; Takeda, Nobuakira; Singh, Manjeet; Lukas, Anton

• ISBN13: 9781402071959
• ISBN10: 1402071957
• Format: Hardcover
• Copyright: 2003-01-01
• Publisher: Springer Verlag

Summary

Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.

Table of Contents

Dedication: A Tribute to Dr. Lionel Opie	xi
Preface	xiii
Acknowledgments	xv
I. ISCHEMIA/REPERFUSION INJURY: BASIC MECHANISMS
PTCA Acutely Expands Perfused Myocardial Mass and Increases Flow Homogeneity	3	(10)
Gianmario Sambuceti
Mario Marzilli
Andrea Mari
Cecilia Marini
Mathis Schluter
Paolo Marzullo
Antonio L'Abbate
Angiogenic Therapy by Coronary Collateral Recruitment and Arteriogenesis	13	(10)
Masatoshi Fujita
Regulatory Role of ERK-Dependent Pathways in Activity of the Na+/H+ Exchanger in the Healthy and Ischemic Myocardium	23	(12)
Larry Fliegel
Morris Karmazyn
Andrea N. Moor
Sodium Overload and Mitochondrial Damage in Ischemic/Reperfused Heart	35	(26)
Satoshi Takeo
Takeshi Iwai
Kouichi Tanonaka
Antisense-Induced Underexpression of Manganese Superoxide Dismutase Extends Myocardial Ischemia-Reperfusion Injury	61	(10)
Shiro Hoshida
Nobushige Yamashita
Kinya Otsu
Masatsugu Hori
Phospholamban Phosphorylation During Ischemia and Reperfusion Injury: Mechanisms and Functional Implications	71	(12)
Alicia Mattiazzi
Cecilia Mundina-Weilenmann
Leticia Vittone
Matilde Said
Paola Ferrero
Phospholipase C-Mediated Signaling in Ischemic Heart Disease	83	(12)
Paramjit S. Tappia
Girma Asemu
Naranjan S. Dhalla
Effects of Sequential Ischemia-Reperfusion Cycles on Cyclic Nucleotide Phosphodiesterase Activity in Pig Heart	95	(32)
Thomas Podzuweit
Markus Schmook
Klaus Binz
Sylvia Thomas
Inducible Nitric Oxide Synthase in Cardiac Adaption to Ischemia	127	(12)
Jan Slezak
Jan Styk
Olga Slezakova
Gerd Wallukat
Peter Karczewski
Wolfgang Schulze
Igor B. Buchwalow
Long Term Follow-Up of Leukocyte Function During Myocardial Reperfusion Injury	139	(10)
Elizabeth Roth
Gabor Jancso
Gyula Temes
Janos Lantos
Mechanisms of Cellular Alterations Due to Ischemia-Reperfusion Injury in the Heart	149	(16)
Rana Temsah
Thomas Netticadan
Naranjan S. Dhalla
Mechanisms for Ischemia/Reperfusion Injury: Application of 23Na Magnetic Resonance Spectroscopy	165	(16)
Kenichi Imahashi
Hideo Kusuoka
II. MECHANISMS UNDERLYING ISCHEMIC PRECONDITIONING-INDUCED CARDIOPROTECTION
Is Reduced Cell Swelling a Plausible End-Effector of Ischemic Preconditioning Protection?	181	(8)
Charles E. Ganote
Stephen C. Armstrong
Cardioprotection by Mitochondrial KATP Channel in Both Early and Late Preconditioning	189	(16)
Yigang Wang
Meifeng Xu
Mitsuhiro Kudo
Ahmar Ayub
Muhammad Ashraf
Role of Mitochondrial Membrane Potential in Cardiac Protection Against Ischemia	205	(14)
Meifeng Xu
Yigang Wang
Ahmar Ayub
Muhammad Ashraf
Hypoxic Reperfusion After Brief Ischemia Potentiates Ischemic Preconditioning in Isolated Rat Hearts	219	(16)
Marie-Claire Toufektsian
Stcphane Tanguy
Sandrine Morel
Nada Benajiba
Francois Boucher
Joel de Leiris
Molecular Basis for the Cardioprotective Effect of Herbal Drugs in Ischemic Heart Disease: An Experimental Study	235	(14)
Suresh Kumar Gupta
Meenu Sharma
Ipseeta Mohanty
Dharamvir S. Arya
Ischaemic and Pharmacological Preconditioning is Associated with Attenuation of p38 MAPK Activation During Sustained Ischaemia and Reperfusion	249	(26)
Amanda Lochner
Erna Marais
Sonia Genade
Barbara Huisamen
Hans Strijdom
Johan A. Moolman
A Role for the Phosphatidylinositol-3-Kinase Pathway in Preconditioning	275	(8)
Elizabeth Murphy
Haiyan Tong
Charles Steenbergen
Myofilament Calcium Responsiveness in Stunning and Preconditioning	283	(10)
Nestor Gustavo Perez
How to Mediate Cardioprotection in Ischemic Hearts---Role of Adenosine	293	(24)
Masafumi Kitakaze
On the Role of Adenosine in Classical and Interorgan Preconditioning of the Heart	317	(12)
David A. Liem
Dennis Susa
Andre Heinen
Willemijn E. Bos
Pieter D. Verdouw
Dirk J. Duncker
Adenosine A3 Receptor Induced Delayed Preconditioning: Essential Role of Nuclear Factor κB, Nitric Oxide Synthase and Mitochondrial KATP Channels	329	(18)
Ting C. Zhao
Rakesh C. Kukreja
Activation of Adenosine A1 and A3 Receptors Protects Mitochondria During Hypoxia in Cardiomyocytes by Distinct Mechanisms	347	(18)
Vladimir Shneyvays
Dorit Leshem
Liaman K. Mamedova
Asher Shainberg
Non Ischemic Myocardial Preconditioning by Tachycardia and Exercise	365	(10)
Raul Domenech
Pilar Macho
Gina Sanchez
Paulina Donoso
III. ARRHYTHMOGENESIS AND CONTRACTILE DYSFUNCTION DURING ISCHEMIA/REPERFUSION
Myocardial Effects of Sodium-Hydrogen Exchange Inhibition During Resuscitation From Ventricular Fibrillation	375	(14)
Raul J. Gazmuri
Iyad M. Ayoub
Na/H Exchange and Arrhythmia	389	(10)
Keitaro Hashimoto
Etsunobu Nagasawa
Bing-Mei Zhu
Mechanisms of Functional Disturbances of Various HERG Mutations in Patients with Long QT Syndrome 2 (LQT2)	399	(10)
Masayasu Hiraoka
Tadashi Nakajima
Tetsushi Furukawa
Sensitivity to Ischemic Injury in the Diabetic Heart: A Dichotomy Between Susceptibility to Ventricular Arrhythmias and the Size of Myocardial Infarction	409	(14)
Tana Ravingerova
Jan Neckar
Frantisek Kolar
Exercise and Delayed Preconditioning in the Protection of the Heart Against Ventricular Arrhythmias: Crucial Role of Nitric Oxide	423	(20)
Agnes Vegh
James R. Parrat
Laszlo Babai
Zsolt Szigeti
Julius Gy. Papp
Myocardioprotection Against Ischemia and Reperfusion Injury by Endothelin Receptor Antagonists	443	(22)
Suresh K. Gupta
Uma Singh
Role of Lipid Peroxidation in Myocardial Ischemic Injury	465	(16)
Matthew West
Sanjay Srivastava
Aruni Bhatnagar
Involvement of Na+/Ca2+ Exchange in Normal Cardiac Excitation-Contraction Coupling and in Ca2+ Overload During Ischemia and Reperfusion	481	(24)
Hiroshi Satoh
Hideki Katoh
Hajime Terada
Hideharu Hayashi
Modulation of Sarcoplasmic Reticulum Calcium Release as a Cardioprotective Strategy	505	(14)
Riccardo Zucchi
Francesca Ronca
Simonetta Ronca-Testoni
Early Detection of Ischemic Myocardial Damage by Glycogen Phosphorylase Isoenzyme BB: A Biomarker for Evaluation of Chest Pain and Evolving Infarction in Patients	519	(14)
Ernst-Georg Krause
Georg Rabitzsch
Franz Noll
Index	533