Myocardial Viability : A Clinical and Scientific Treatise

by Dilsizian, Vasken

• ISBN13: 9780879934378
• ISBN10: 0879934379
• Format: Hardcover
• Copyright: 2000-01-01
• Publisher: John Wiley & Sons Inc

Summary

Georgetown Univ., Washington, D.C. Bridges the gap between basic cellular physiology and clinical decision making as it relates to myocardial viability, clinical experience in recent years, and techniques most useful in clinical practice. For researchers and clinicians. Halftone illustrations and extensive references are included. DNLM: Myocardium--pathology.

Author Biography

H. Vernon Anderson, MD: Professor of Medicine, University of Texas-Houston Medical School Stephen L. Bacharach, PhD: Head, Imaging Science Group, Clinical Center, National Institutes of Health, Bethesda, Maryland Robert O. Bonow, MD: Goldberg Distinguished Professor of Medicine, Chief, Division of Cardiology, Northwestern Medical School, Chicago, Illinois Peter R. Brink, PhD: Department of Physiology and Biophysics, and the Institute for Molecular Cardiology, School of Medicine, State University of New York at Stonybrook Madhulika Chandra, MD: Research Fellow, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York Michael V. Cohen, MD: Professor of Medicine, Division of Cardiology, College of Medicine, University of South Alabama, Mobile Vasken Dilsizian, MD: Director of Nuclear Cardiology, National Institutes of Health, Bethesda, Maryland, Adjunct Professor of Medicine and Radiology, Georgetown University School of Medicine, Adjunct Professor of Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC James M. Downey, PhD: Professor of Physiology, Department of Physiology, College of Medicine, University of South Alabama William T. Evanochko, PhD: Associate Professor of Medicine, Division of Cardiovascular Disease, The University of Alabama at Birmingham, School of Medicine/Department of Medicine Ludwig E. Feinendegen, MD: Fogarty Scholar, Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, Emeritus Professor of Nuclear Medicine, Heinrich-Heine University of Dusseldorf, Germany Joanne S. Ingwall, PhD: Professor of Medicine (Physiology), NMR Laboratory for Physiological Chemistry, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Ada Jain, MD: Summer Research Fellow, Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Illinois Francis J. Klocke, MD: Director, Feinberg Cardiovascular Research Institute, Division of Cardiology, Department of Medicine and Department of Surgery, Professor of Medicine, Northwestern University Medical School, Chicago, Illinois Mark A. Lawson, MD: Fellow, Division of Cardiovascular Disease, The University of Alabama at Birmingham, School of Medicine/Department of Medicine Marc Ovadia, MD: Assistant Professor of Pediatrics (Cardiology), Cornell Medical College, Boas Marks Biomedical Research Facility, Manhasset, New York Gerald M. Pohost, MD: Mary Gertrude Waters Chair in Cardiovascular Medicine, Professor of Medicine and Radiology, Division of Cardiovascular Disease, The University of Alabama at Birmingham, School of Medicine/Department of Medicine Vera H. Rigolin, MD: Assistant Professor of Medicine, Division of Cardiology, Northwestern University, Chicago, Illinois Raymond R. Russell III, MD: Yale University School of Medicine, New Haven, Connecticut Thomas J. Ryan, MD: Professor of Medicine, Department of Cardiology, Boston University School of Medicine, Massachusetts Heinrich R. Schelbert, MD, PhD: Professor of Pharmacology and Radiological Sciences, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles Heiko Schoder, MD: Ahmanson Biological Imaging Clinic, Nuclear Medicine UCLA School of Medicine, CHS, Los Angeles Andrew J. Sherman, MD: Research Fellow of the Thoracic Surgery Foundation for Research and Education, Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Illinois Jamshid Shirani, MD: Associate Professor of Clinical Medicine and Pathology, Albert Einstein College of Medicine, Division of Cardiology, Bronx, New York Edmund H. Sonnenblick, MD: Edmond J. Safra Professor of Medicine, Albert Einstein College of Medicine, Division of Cardiology, Bronx, New York Heinrich Taegtmeyer, MD, DPhil: Professor of Medicine, Co-Director, Division of Cardiology, The University of Texas Houston Medical School William J. Thoma, PhD: Instructor, Division of Cardiovascular Disease, The University of Alabama at Birmingham, School of Medicine/Department of Medicine James T. Willerson, MD: Medical Director; Director of Cardiology Research; Co-Director, Cullen Cardiovascular Research Laboratories, Texas Heart Institute, Houston

Table of Contents

Contributors	p. vii
Preface	p. ix
Introduction
Perspectives on the Study of Human Myocardium: Viability	p. 3
Basic Concepts and Mechanisms
Modulation of Responses to Myocardial Ischemia: Metabolic Features of Myocardial Stunning, Hibernation, and Ischemic Preconditioning	p. 25
Reversible Myocardial Dysfunction: Stunning, Hibernation, or What?	p. 37
Preconditioning	p. 55
Vascular Biology and Cellular Physiology
Experimental Models Useful in Evaluating Myocardial Viability	p. 79
Essential Fuels for the Heart and Mechanical Restitution	p. 91
Nitric Oxide and Energetics of the Heart: Physiology and Pathophysiology	p. 105
Channels, Ischemia, and Stunning: Cellular Electrophysiology and Intercellular Communication	p. 115
Advances in Functional Imaging
New Methods for Measurement of Regional and Global Ventricular Function	p. 163
Myocardial Contractile Reserve	p. 181
Morphological and Echocardiographic Features of Viable and Nonviable Myocardium	p. 207
Timing and Myocardial Salvage: Lessons Learned From the Thrombolytic and Revascularization Multicenter Trials	p. 233
Perfusion, Metabolism, and Cell Membrane Integrity
Introduction to Tracer Kinetics	p. 251
Thallium-201 Scintigraphy: Experience of Two Decades	p. 265
Technetium-99m-Labeled Myocardial Perfusion Tracers: Blood Flow or Viability Agents?	p. 315
Myocardial Imaging of Lipid Metabolism with Labeled Fatty Acids	p. 349
Positron Emission Tomography for the Assessment of Myocardial Viability: Noninvasive Approach to Cardiac Pathophysiology	p. 391
Nuclear Magnetic Resonance and Myocardial Viability	p. 419
Index	p. 437
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