Nanofluidics

by Abgrall, Patrick; Nguyen, Nam-Trung

• ISBN13: 9781596933507
• ISBN10: 159693350X
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-07-31
• Publisher: Artech House

Summary

Taking you to the forefront of the emerging field of Nanofluidics, this cutting-edge book details the physics and applications of fluid flow in nanometer scale channels. You gain a solid understanding of the fundamental aspects of transport processes and force interactions in microscale. Moreover, this unique resource presents the latest research on nanoscale transport phenomena. You find a comprehensive overview of fabrication technologies for nanotachnologies, including detailed technology recipes and parameters. The book concludes with a look at future trends and the likely directions this new field will take.

Author Biography

Patrick Abgrall is a postdoctoral researcher at the Biomedical Diagnostics Institute in Dublin. He earned his Ph.D. with a thesis on polymer fabrication for lab-on-chips at LAAS-CNRS in Toulouse, France. He was a member of the Singapore-MIT alliance, where his research was focused on the fabrication and applications of polymer nanofluidic devices. Nam-Trung Nguyen is an associate professor at the School of Mechanical and Aerospace Engineering at Nanyang Technological University. He received his M.Sc. and Ph.D. and Dr. Ing. habil. in electrical engineering from Chemnitz University of Technology, Germany.

Table of Contents

Introduction	p. 1
Classical Areas Related to Nanofluidics	p. 1
Technology Developments Leading to Nanofluidics	p. 3
New Phenomena and Applications of Nanofluidics	p. 4
Organization of the Book	p. 6
Fundamentals of Mass Transport at the Nanoscale	p. 9
Fluid Flow at the Microscale	p. 9
Scaling Laws	p. 9
Continuum Model	p. 11
Pressure-Driven Flow	p. 13
Capillary Flow	p. 19
Electrokinetic Flow	p. 22
Mixing in Microscale	p. 34
From Microscale to Nanoscale	p. 41
Continuum Assumption	p. 41
Kinetic Theory	p. 43
Molecular Dynamics and Direct Simulation Monte Carlo (DSMC)	p. 46
Diffusion in Nanochannels	p. 48
Knudsen Diffusion in Nanochannels	p. 48
Hindered Diffusion in Nanochannels	p. 49
Electrokinetics in Nanochannels	p. 49
Water in Nanochannels	p. 51
Capillary Filling in a Nanochannel	p. 53
Modeling of the Filling Process	p. 53
Asymptotic Solutions	p. 59
Nanofilters	p. 63
Electrostatic Effect	p. 64
Reptation Effect	p. 65
Steric Effect	p. 66
Entropic Effect	p. 66
References	p. 67
Selected Bibliography	p. 69
Fabrication Technologies of Nanochannels	p. 71
Basics About Micro-and Nanofabrication	p. 71
Silicon/Glass Micro-and Nanofabrication	p. 72
Polymer Micro-and Nanofabrication	p. 103
Application to Micro-and Nanofluidic Systems	p. 109
Microfluidic Devices	p. 117
Nanofluidic Devices	p. 117
References	p. 127
Applications of Micro-and Nanofluidics	p. 141
Microfluidics and Lab-on-Chips	p. 142
Biomolecular Analyses	p. 142
Microfluidics Beyond Biomolecular Analyses	p. 155
Handling Ions by Electrokinetic Effects in Nanochannels	p. 159
Nanofluidic Resistors as Surface Charge Sensors	p. 159
Semipermeability and Preconcentration	p. 163
Routing Ions by Nanofluidic Electronics	p. 167
Separations in Nanofluidic Devices	p. 170
Batch Separations	p. 170
Continuous-Flow Separations	p. 174
Linear Analysis of Biomolecules	p. 178
Why Stretching DNA?	p. 178
Sizing Confined DNA?	p. 179
Nanopore Sequencing	p. 180
References	p. 181
Conclusion	p. 197
About the Authors	p. 199
Index	p. 201
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