Negative Co-Receptors and Ligands

by Ahmed, Rafi; Honjo, Tasuku

• ISBN13: 9783642195440
• ISBN10: 364219544X
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-04-12
• Publisher: Springer Verlag

Summary

Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules.

Table of Contents

TIM-3 and Its Regulatory Role in Immune Responses	p. 1
Role of PD-1 in Regulating T-Cell Immunity	p. 17
The Role of IL-10 in Regulating Immunity to Persistent Viral Infections	p. 39
Inhibitory Ly49 Receptors on Mouse Natural Killer Cells	p. 67
Immunoregulatory Roles for Fc Receptor-Like Molecules	p. 89
FCYRS in Health and Disease	p. 105
TGF-0 Function in Immune Suppression	p. 127
Index	p. 149
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