Neglected Tropical Diseases and Phytochemicals in Drug Discovery

by Egbuna, Chukwuebuka; Akram, Muhammad; Ifemeje, Jonathan Chinenye

• ISBN13: 9781119616603
• ISBN10: 1119616603
• Edition: 1st
• Format: Hardcover
• Copyright: 2021-11-09
• Publisher: Wiley

Summary

NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY

Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases

Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections.

This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals.

The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of:

• Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases
• An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis
• Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals
• Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis

Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Author Biography

Chukwuebuka Egbuna is a Research Biochemist in the Department of Biochemistry at Chukwuemeka Odumegwu Ojukwu University in Nigeria. He is a reviewer and editorial board member of several journals.

Muhammad Akram, PhD, is Associate Professor in the Department of Eastern Medicine at the Government College University in Faisalabad, Pakistan. He has published numerous scholarly articles and is an editor and reviewer for several national and international journals.

Jonathan Chinenye Ifemeje, PhD, is Professor in the Department of Biochemistry at Chukwuemeka Odumegwu Ojukwu University in Nigeria. He is Managing Editor of the Tropical Journal of Applied Natural Sciences.

Table of Contents

Preface

PART I: Introduction to Neglected Tropical Diseases

Chapter 1: Epidemiology of neglected tropical diseases

Kurubaran Ganasegeran

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Chapter 2: Neglected Tropical Diseases, Phytochemicals, Protein Targets and Mechanisms in Drug Discovery

Lalit R. Samant

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Chapter 3: Novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis (African sleeping sickness and Chagas disease) and schistosomiasis

Abeer M. El Sayed

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PART II: Protozoan Infections

 

Chapter 4: Herbal, nutritional and traditional remedies for giardiasis: Phytochemicals as drug candidates

Samrat Bhattacharyya

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Chapter 5: Antiprotozoal activity of phytochemicals against Entamoeba histolytica, the causative agent of Amoebiasis

Goutam Jena

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Chapter 6: Anti-leishmanial potentials of phytochemicals

Shahira Mohamed Ezzat

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Part III: Helminth Infections

Chapter 7: Prospects of phytochemicals in the treatment of helminthiasis

Muhammad Akram

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Chapter 8: Efficacy of phytochemicals of medicinal plants for the treatment of human echinococcosis: Echinococcal disease, hydatidosis or hydatid disease drug discovery

Charles Oluwaseun Adetunji

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Chapter 9: Filaricidal activity of phytochemicals against lymphatic filariasis

Sharangouda J. Patil

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Chapter 10: Dracunculiasis (Guinea worm disease) and phytochemicals in drug discovery

Muhammad Akram

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Chapter 11: Medicinal potentials of phytochemicals as a source of drugs for the treatment of onchocerciasis (River blindness)

Chandrashekar Srinivasa

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Chapter 12: Foodborne trematodiases and phytochemicals

Ramith Ramu

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Part IV: Bacterial Infections

Chapter 13: Bacteriocidal effects of phytochemicals on Mycobacterium ulcerans, the causative agents of Buruli ulcer

Alloysius Chibuike Ogodo

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Chapter 14: Bacteriocidal effects of phytochemicals on Mycobacterium leprae, the causative agent of Leprosy

Chukwuebuna Egbuna

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Chapter 15 Medicinal plants and phytochemicals effective against Chlamydia trachomatis, the causative agent of trachoma

Habibu Tijjani

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Chapter 16: Yaws (Endemic treponematoses) drug discovery from phytochemicals: An informatics protocol for drug target identification to phytochemical inhibitor screening and validation

Zarrin Basharat

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Part V: Viral Infections

Chapter 17: Dengue fever: a brief overview and insights into the potential applicability of phytochemicals in its management

Muhammad Akram

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Chapter 18: Medicinal potentials of phytochemicals for the management of rabies

Chandan Shivamallu

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Part VI: Fungal and Ectoparasitic Infections

Chapter 19: Roles of medicinal plants in the diagnosis and treatment of Eumycetoma

Chinaza Godswill Awuchi

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Chapter 20: Role of phytochemicals in the treatment of ectoparasitic infections: Scabies and myiasis

Santwana Palai

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Part VII: Non Classified NTDs: Malaria and Human Tuberculosis

Chapter 21: Malaria and recent developments in antimalarial drugs

Mithun Rudrapal

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Chapter 22: Therapeutic potentials of phytochemicals against Mycobacterium tuberculosis, the causative agents of Tuberculosis

Alloysius Chibuike Ogodo

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Index